Essential hypertension

Active Ingredient: Azilsartan medoxomil

Indication for Azilsartan medoxomil

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Azilsartan medoxomil is indicated for the treatment of essential hypertension in adults.

For this indication, competent medicine agencies globally authorize below treatments:

40-80 mg once a day

For:

Dosage regimens

Oral, 40 milligrams azilsartan medoxomil, once daily. Afterwards, oral, between 40 milligrams azilsartan medoxomil and 80 milligrams azilsartan medoxomil, once daily.

Detailed description

The recommended starting dose is 40 mg once daily. The dose may be increased to a maximum of 80 mg once daily for patients whose blood pressure is not adequately controlled at the lower dose.

Near-maximal antihypertensive effect is evident at 2 weeks, with maximal effects attained by 4 weeks.

If blood pressure is not adequately controlled with (azilsartan medoxom alone, additional blood pressure reduction can be achieved when this treatment is coadministered with other antihypertensive medicinal products, including diuretics (such as chlortalidone and hydrochlorothiazide) and calcium channel blockers.

Dosage considerations

Azilsartan medoxomil is for oral use and may be taken with or without food.

20-80 mg once daily

For:

Dosage regimens

Oral, between 20 milligrams azilsartan medoxomil and 40 milligrams azilsartan medoxomil, once daily. Afterwards, oral, between 20 milligrams azilsartan medoxomil and 80 milligrams azilsartan medoxomil, once daily.

Detailed description

No initial dose adjustment with azilsartan medoxomil is necessary in elderly patients, although consideration can be given to 20 mg as a starting dose in the very elderly (≥75 years), who may be at risk of hypotension.

The recommended starting dose in adults is 40 mg once daily. The dose may be increased to a maximum of 80 mg once daily for patients whose blood pressure is not adequately controlled at the lower dose.

Near-maximal antihypertensive effect is evident at 2 weeks, with maximal effects attained by 4 weeks.

If blood pressure is not adequately controlled with azilsartan medoxomil alone, additional blood pressure reduction can be achieved when this treatment is coadministered with other antihypertensive medicinal products, including diuretics (such as chlortalidone and hydrochlorothiazide) and calcium channel blockers.

Dosage considerations

Azilsartan medoxomil is for oral use and may be taken with or without food.

Active ingredient

Azilsartan medoxomil

Azilsartan medoxomil is an orally active prodrug that is rapidly converted to the active moiety, azilsartan, which selectively antagonises the effects of angiotensin II by blocking its binding to the AT1 receptor in multiple tissues. Angiotensin II is the principal pressor agent of the RAAS, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium.

Read more about Azilsartan medoxomil

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