Acute adrenal insufficiency

Indication for Cortisol

Population group: Suitable for both men and women, only newborns (0 - 40 days old) , infants (40 days - 1 year old) , children (1 year - 12 years old)

Acute adrenal insufficiency caused by abnormal stress in Addison’s disease, hypopituitarism, following adrenalectomy, and when adrenocortical function has been suppressed by prolonged corticosteroid therapy.

For this indication, competent medicine agencies globally authorize below treatments:

25-400 mg in 1-4 divided doses daily

Route of admnistration


Defined daily dose

25 - 400 mg

Dosage regimen

From 6.25 To 100 mg 4 time(s) per day every day

Detailed description

As a guide, infants up to 1 year may be given 25mg hydrocortisone intravenously; children 1 to 5 years, 50mg; 6 to 12 years, 100mg. This dose can be repeated three or four times in 24 hours depending upon the condition being treated and the patient’s response.

Dosage considerations

Slow intravenous injection, taking at least half to one minute.

Active ingredient

Hydrocortisone is the main glucocorticoid secreted by the adrenal cortex. Hydrocortisone is an anti-inflammatory steroid. Its anti-inflammatory action is due to reduction in the vascular component of the inflammatory response and reduction in the formation of inflammatory fluid and cellular exudates.

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