Hydrocortisone Other names: Cortisol

Chemical formula: C₂₁H₃₀O₅  Molecular mass: 362.46 g/mol  PubChem compound: 5754

Active ingredient description

Hydrocortisone is the main glucocorticoid secreted by the adrenal cortex. Hydrocortisone is an anti-inflammatory steroid. Its anti-inflammatory action is due to reduction in the vascular component of the inflammatory response and reduction in the formation of inflammatory fluid and cellular exudates.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
A01AC03 Hydrocortisone A Alimentary tract and metabolism → A01 Stomatological preparations → A01A Stomatological preparations → A01AC Corticosteroids for local oral treatment
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A07EA02 Hydrocortisone A Alimentary tract and metabolism → A07 Antidiarrheals, intestinal antiinflammatory/antiinfective agents → A07E Intestinal antiinflammatory agents → A07EA Corticosteroids acting locally
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C05AA01 Hydrocortisone C Cardiovascular system → C05 Vasoprotectives → C05A Agents for treatment of hemorrhoids and anal fissures for topical use → C05AA Corticosteroids
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D07AA02 Hydrocortisone D Dermatologicals → D07 Corticosteroids, dermatological preparations → D07A Corticosteroids, plain → D07AA Corticosteroids, weak (group I)
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D07AB11 Hydrocortisone buteprate D Dermatologicals → D07 Corticosteroids, dermatological preparations → D07A Corticosteroids, plain → D07AB Corticosteroids, moderately potent (group II)
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D07AC16 Hydrocortisone aceponate D Dermatologicals → D07 Corticosteroids, dermatological preparations → D07A Corticosteroids, plain → D07AC Corticosteroids, potent (group III)
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D07XA01 Hydrocortisone D Dermatologicals → D07 Corticosteroids, dermatological preparations → D07X Corticosteroids, other combinations → D07XA Corticosteroids, weak, other combinations
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H02AB09 Hydrocortisone H Systemic hormonal preparations, excl. Sex hormones and insulins → H02 Corticosteroids for systemic use → H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN → H02AB Glucocorticoids
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S01BA02 Hydrocortisone S Sensory organs → S01 Ophthalmologicals → S01B Antiinflammatory agents → S01BA Corticosteroids, plain
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S01CB03 Hydrocortisone S Sensory organs → S01 Ophthalmologicals → S01C Antiinflammatory agents and antiinfectives in combination → S01CB Corticosteroids/antiinfectives/mydriatics in combination
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S02BA01 Hydrocortisone S Sensory organs → S02 Otologicals → S02B Corticosteroids → S02BA Corticosteroids
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Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
HYDROCORTISONE Cream Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
HYDROCORTISONE Solution for injection Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
ALKINDI Granule in capsule Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
HYDROCORTISONE 1% w/w Ointment Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
CORTENEMA Enema FDA, National Drug Code (US) MPI, US: SPL/Old
CORTEF Tablet FDA, National Drug Code (US) MPI, US: SPL/Old
HYDROCORTISONE Tablet Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

3D molecular structure

3D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 125-04-2
CAS Substance: 50-03-3
CAS Substance: 50-23-7
DrugBank Drug: DB00741
KEGG Drug: D00088
PubChem Compound: 5754
RxNorm Ingredient: 5492
SNOMED-CT Concept: 396458002
Hydrocortisone (substance)
UNII Identifier: WI4X0X7BPJ
HYDROCORTISONE

Medicines

Hydrocortisone is an active ingredient of these brands:

United States (US)

Australia (AU)

Austria (AT)

Brazil (BR)

Canada (CA)

Croatia (HR)

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Germany (DE)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Italy (IT)

Japan (JP)

Lithuania (LT)

Malta (MT)

Mexico (MX)

  • (combination) ORECIL NF as HYDROCORTISONE HEMISUCCINATE
  • (combination) OTO ENI
  • (combination) XYLOPROCT as HYDROCORTISONE ACETATE

Netherlands (NL)

New Zealand (NZ)

Nigeria (NG)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

Tunisia (TN)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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