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ATC Group: A07EA Corticosteroids acting locally

Anatomical Therapeutic Chemical Classification System

Hierarchical Position

Level
Code
Title
1
A
Alimentary tract and metabolism
2
A07
Antidiarrheals, intestinal antiinflammatory/antiinfective agents
3
A07E
Intestinal antiinflammatory agents
4
A07EA
Corticosteroids acting locally

Contents

Code
Title
A07EA01
Prednisolone
A07EA02
Hydrocortisone
A07EA03
Prednisone
A07EA04
Betamethasone
A07EA05
Tixocortol
A07EA06
Budesonide
A07EA07
Beclometasone

Active Ingredients

Chemical substance
Description
Beclometasone

Beclometasone is a pro-drug with weak glucocorticoid receptor binding affinity. It is extensively hydrolysed via esterase enzymes to the active metabolite beclometasone-17-monopropionate (B-17-MP), which has potent topical anti-inflammatory activity.

Betamethasone

Betamethasone is a glucocorticoid which is about eight to ten times as active as prednisolone on a weight-for-weight basis. Betamethasone has anti-inflammatory, antipruritic, and vasoconstrictive properties.

Budesonide

Budesonide is a glucocorticosteroid with a high local anti-inflammatory effect. At doses clinically equivalent to systemically acting glucocorticosteroids, budesonide gives significantly less HPA axis suppression and has a lower impact on inflammatory markers.

Cortisol

Hydrocortisone is the main glucocorticoid secreted by the adrenal cortex. Hydrocortisone is an anti-inflammatory steroid. Its anti-inflammatory action is due to reduction in the vascular component of the inflammatory response and reduction in the formation of inflammatory fluid and cellular exudates.

Prednisolone

Prednisolone is a glucocorticoid which has anti-inflammatory activity. Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs are primarily used for their potent anti-inflammatory effects in disorders of many organ systems.

Prednisone

Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations.

Tixocortol

Tixocortol is a 21-thiol derivative of hydrocortisone classified as a class A corticosteroid. It is a synthetic steroid with topical anti-inflammatory properties without the systemic glucocorticoid and mineralocorticoid activities and toxicity.

Monographs

Monograph
Type
Country
BUDENOFALK Gastro-resistant capsule
MPI, EU: SmPC
UK
BUDENOFALK Rectal foam
MPI, EU: SmPC
UK
CLIPPER Gastro-resistant prolonged-release tablet
MPI, EU: SmPC
UK
CORTENEMA Enema
MPI, US: SPL/Old
US
ENTOCORT CR Capsule
MPI, EU: SmPC
UK
ENTOCORT Enema
MPI, EU: SmPC
UK