Prednisolone

Chemical formula: C₂₁H₂₈O₅  Molecular mass: 360.444 g/mol  PubChem compound: 5755

Active ingredient description

Prednisolone is a glucocorticoid which has anti-inflammatory activity. Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs are primarily used for their potent anti-inflammatory effects in disorders of many organ systems.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
A01AC04 A Alimentary tract and metabolism → A01 Stomatological preparations → A01A Stomatological preparations → A01AC Corticosteroids for local oral treatment
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A07EA01 Prednisolone A Alimentary tract and metabolism → A07 Antidiarrheals, intestinal antiinflammatory/antiinfective agents → A07E Intestinal antiinflammatory agents → A07EA Corticosteroids acting locally
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C05AA04 Prednisolone C Cardiovascular system → C05 Vasoprotectives → C05A Agents for treatment of hemorrhoids and anal fissures for topical use → C05AA Corticosteroids
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D07AA03 Prednisolone D Dermatologicals → D07 Corticosteroids, dermatological preparations → D07A Corticosteroids, plain → D07AA Corticosteroids, weak (group I)
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D07XA02 Prednisolone D Dermatologicals → D07 Corticosteroids, dermatological preparations → D07X Corticosteroids, other combinations → D07XA Corticosteroids, weak, other combinations
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H02AB06 Prednisolone H Systemic hormonal preparations, excl. Sex hormones and insulins → H02 Corticosteroids for systemic use → H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN → H02AB Glucocorticoids
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R01AD02 Prednisolone R Respiratory system → R01 Nasal preparations → R01A Decongestants and other nasal preparations for topical use → R01AD Corticosteroids
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S01BA04 Prednisolone S Sensory organs → S01 Ophthalmologicals → S01B Antiinflammatory agents → S01BA Corticosteroids, plain
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S01CB02 Prednisolone S Sensory organs → S01 Ophthalmologicals → S01C Antiinflammatory agents and antiinfectives in combination → S01CB Corticosteroids/antiinfectives/mydriatics in combination
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S02BA03 Prednisolone S Sensory organs → S02 Otologicals → S02B Corticosteroids → S02BA Corticosteroids
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S03BA02 Prednisolone S Sensory organs → S03 Ophthalmological and otological preparations → S03B Corticosteroids → S03BA Corticosteroids
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Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
PEDIAPRED Oral solution FDA, National Drug Code (US) MPI, US: SPL/Old
PREDNISOLONE Suspension for injection Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
MINIMS PREDNISOLONE Single-use eye drops Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
PRED FORTE Eye drops, suspension FDA, National Drug Code (US) MPI, US: SPL/Old
PREDNISOLONE Suppositories Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
PRED MILD Eye-drops, suspension FDA, National Drug Code (US) MPI, US: SPL/Old
PREDNISOLONE Tablet Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

3D molecular structure

3D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 125-02-0
CAS Substance: 50-24-8
CAS Substance: 52-21-1
DrugBank Drug: DB00860
KEGG Drug: D00472
PubChem Compound: 5755
RxNorm Ingredient: 8638
SNOMED-CT Concept: 116601002
Prednisolone (substance)
UNII Identifier: 9PHQ9Y1OLM
PREDNISOLONE

Medicines

Prednisolone is an active ingredient of these brands:

United States (US)

Australia (AU)

Austria (AT)

Brazil (BR)

Canada (CA)

Croatia (HR)

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Germany (DE)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Japan (JP)

  • LIDOMEX as PREDNISOLONE VALERATE ACETATE
  • PREDONEMA as PREDNISOLONE SODIUM PHOSPHATE
  • PREDONINE as PREDNISOLONE SODIUM SUCCINATE
  • SPIRAZON as PREDNISOLONE VALERATE ACETATE

Lithuania (LT)

Malta (MT)

Mexico (MX)

Netherlands (NL)

New Zealand (NZ)

Nigeria (NG)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

Tunisia (TN)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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