Active Ingredient: Aliskiren
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 150 milligrams aliskiren, once daily. Afterwards, oral, between 150 milligrams aliskiren and 300 milligrams aliskiren, once daily.
The recommended dose of aliskiren is 150 mg once daily. In patients whose blood pressure is not adequately controlled, the dose may be increased to 300 mg once daily.
The antihypertensive effect is substantially present within two weeks (85‑90%) after initiating therapy with 150 mg once daily.
Aliskiren may be used alone or in combination with other antihypertensive agents with the exception of use in combination with angiotensin converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARB) in patients with diabetes mellitus or renal impairment (glomerular filtration rate (GFR) <60 ml/min/1.73 m²).
The recommended starting dose of aliskiren in elderly patients is 150 mg. No clinically meaningful additional blood pressure reduction is observed by increasing the dose to 300 mg in the majority of elderly patients.
Aliskiren should be taken once a day, always with or always without food, preferably at the same time each day. Patients should establish a convenient daily schedule of medicinal product intake and maintain a steady temporal relationship with food intake. Concomitant intake with fruit juice and/or drinks containing plant extracts (including herbal teas) should be avoided.
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