Aliskiren is an orally active, non-peptide, potent and selective direct inhibitor of human renin. By inhibiting the enzyme renin, aliskiren inhibits the RAAS at the point of activation, blocking the conversion of angiotensinogen to angiotensin I and decreasing levels of angiotensin I and angiotensin II.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
Aliskiren is the active ingredient of these drugs:
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Aliskiren is also found within below combination drugs:
Medicine agencies around the world have authorized marketing of this active ingredient according to these medication package inserts (MPIs):