Chemical formula: C₃₀H₅₃N₃O₆  Molecular mass: 551.758 g/mol  PubChem compound: 5493444

Therapeutic indications

Aliskiren is indicated for:

Essential hypertension

Population group: only adults (18 years old or older)

Essential hypertension

For this indication, competent medicine agencies globally authorize below treatments (click for details):


Aliskiren is contraindicated in the following cases:

Hereditary or idiopathic angioedema

at least one of
Idiopathic angio-oedema
Hereditary angioneurotic edema





ACEI or ARB in patients with diabetes mellitus or renal impairment

at least one of
ACE inhibitors, plain
Angiotensin II antagonists, plain and additionally at least one of
Diabetes mellitus

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

History of angioedema with aliskiren


P-gp potent inhibitors

P-glycoprotein inhibitors

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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