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Solu-Cortef (2012)

Active ingredients: Cortisol

Pharmacodynamic properties

Hydrocortisone sodium succinate has the same metabolic and anti-inflammatory actions as hydrocortisone. It is a glucocorticosteroid. Used in pharmacological doses, its actions supress the clinical manifestations of disease in a wide range of disorders.

Pharmacokinetic properties

Twelve normal subjects received 100, 200 or 400 mg Solu-Cortef intravenously. Radio-immunoassay results were as follows:-

DOSE (mg)CMAX (mcg/100 ml)TMAX (hr)12-HR AUC (mG/100 ml x hr)
100132.30.35418.0
200231.80.25680.0
400629.80.371024.0

In another study, a 1 mg/kg i.m. dose of Solu-Cortef peaked in 30-60 minutes, with a plasma cmax of 80 mg/100 ml.

In analysing hydrocortisone metabolism, a 25 mg IV dose resulted in higher plasma concentrations in females than in males.