Active ingredients: Cortisol
Hydrocortisone sodium succinate has the same metabolic and anti-inflammatory actions as hydrocortisone. It is a glucocorticosteroid. Used in pharmacological doses, its actions supress the clinical manifestations of disease in a wide range of disorders.
Twelve normal subjects received 100, 200 or 400 mg Solu-Cortef intravenously. Radio-immunoassay results were as follows:-
|DOSE (mg)||CMAX (mcg/100 ml)||TMAX (hr)||12-HR AUC (mG/100 ml x hr)|
In another study, a 1 mg/kg i.m. dose of Solu-Cortef peaked in 30-60 minutes, with a plasma cmax of 80 mg/100 ml.
In analysing hydrocortisone metabolism, a 25 mg IV dose resulted in higher plasma concentrations in females than in males.