ADVIL LIQUI-GELS Liquid capsule Ref.[51095] Active ingredients: Ibuprofen

Source: Health Products Regulatory Authority (ZA)  Revision Year: 2021  Publisher: GlaxoSmithKline Consumer Healthcare South Africa (Pty) Ltd, 39 Hawkins Avenue, Epping Industria 1 Cape Town, 7460

5.1. Pharmacodynamic properties

Category A, 2.7 Antipyretic or antipyretic and anti-inflammatory analgesic.

Ibuprofen is a non-steroidal compound, which exhibits anti-inflammatory, analgesic and antipyretic activities.

5.2. Pharmacokinetic properties

After oral administration, solubilized ibuprofen is quickly absorbed when administered after fasting conditions. Cmax is achieved within 0.6 hours when compared with conventional tablets (0.75-1.5 hours). When taken with food, peak plasma levels are observed after 1-2 hours. It is over 90% plasma protein bound in the circulation and has a short elimination half-life of 0.9-2.5 hours.

5.3. Preclinical safety data

No data available.

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