Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2020 Publisher: Almirall Hermal GmbH, Scholtzstrasse 3, D-21465, Reinbek, Germany
Aknemycin Plus 4.0% w/w and 0.025% w/w cutaneous solution.
| Pharmaceutical Form |
|---|
|
Cutaneous solution. Aknemycin Plus is a clear solution for topical administration. |
Each gram of cutaneous solution contains 40 mg of erythromycin and 0.25 mg of tretinoin.
Excipients with known effect:
1 ml of solution contains 752 mg of alcohol (ethanol).
For the full list of excipients, see section 6.1.
| Active Ingredient | Description | |
|---|---|---|
| Erythromycin |
Erythromycin exerts its antimicrobial action by binding to the 50S ribosomal sub-unit of susceptible microorganisms and suppresses protein synthesis. Erythromycin is bacteriostatic and bactericidal depending on its concentration and the type of organism. |
|
| Tretinoin |
Tretinoin decreases cohesiveness of follicular epithelial cells resulting in decreased microcomedone formation. Additionally, tretinoin stimulates mitotic activity and increased turnover of follicular epithelial cells, causing extrusion of the comedones. |
| List of Excipients |
|---|
|
Ethanol |
Amber glass bottle, with white screw cap, containing 25ml Aknemycin Plus. The bottle has a polyethylene stopper which holds a foam pad with a nylon gauze covering. Pack sizes 25ml, 50ml (2 × 25ml).
Almirall Hermal GmbH, Scholtzstrasse 3, D-21465, Reinbek, Germany
PL 33016/0007
31 July 1998
| Drug | Countries | |
|---|---|---|
| AKNEMYCIN PLUS | Poland, Singapore, United Kingdom |
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