ANHYDROL FORTE Cutaneous solution Ref.[49994] Active ingredients: Aluminium chloride

Source: Health Products Regulatory Authority (IE)  Revision Year: 2020  Publisher: Dermal Laboratories (Ireland) Limited, 38 Main Street, Swords, Co Dublin, K67 E0A2, Ireland

5.1. Pharmacodynamic properties

Aluminium chloride is believed to denature the protein content of sweat issuing from eccrine glands, and to combine with the intraductal keratin fibrils, producing a functional closure. The antibacterial action of the aluminium ion also precludes the development of miliaria. Accordingly, there is no secondary inflammation. The intraluminal pressure rises to the point where it acts as a feedback system, shutting off acinar secretion.

The formulation of Anhydrol Forte has been tested in widespread clinical practice, and has been shown to be effective when used in accordance with the recommended instructions.

5.2. Pharmacokinetic properties

As the active ingredient is applied in an alcoholic solution of low surface tension, it therefore penetrates into the terminal pores of the sweat ducts, when applied, as recommended, to dry skin. The alcohol then evaporates off, leaving the salt deposited in close contact with the lining of the duct. The use of the preparation is restricted to small areas of skin, namely the axillae, hands or feet, to ensure that there are no detrimental effects from widespread obstruction of sweating.

5.3. Preclinical safety data

No special information.

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