Active ingredients: Ipratropium
Atrovent 250 UDVs, 1 ml.
Atrovent UDVs, 2 ml.
Each single dose unit contains 0.025% w/v ipratropium bromide i.e. 250 micrograms in 1 ml and 500 micrograms in 2 ml.
For excipients, see 6.1.
Ipratropium is a quaternary ammonium compound with anticholinergic (parasympatholytic) properties. Ipratropium appears to inhibit vagally mediated reflexes by antagonising the action of acetylcholine, the transmitter agent released from the vagus nerve. Anticholinergics prevent the increase in intracellular concentration of Ca++, which is caused by interaction of acetylcholine with the muscarinic receptor on bronchial smooth muscle. Ca++ release is mediated by the second messenger system consisting of IP3 (inositol triphosphate) and DAG (diacylglycerol).
1N Hydrochloric acid
Polyethylene unit dose vials containing either 1 ml or 2 ml of solution.
Pack sizes of 10, 20, 30, 50, 60, 80, 100, 120, 150, 200, 300, 500 and 1000.
Not all pack sizes may be marketed.
Boehringer Ingelheim Limited, Ellesfield Avenue, Bracknell, Berkshire, RG12 8YS
27 August 1986 / 23 December 2005