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Ipratropium

Also known as: Ipratropium bromide

Brand names: ATROVENT BERODUAL (in combination) BERODUALIN (in combination) COMBIVENT (in combination) DUOVENT (in combination) IPRAVENT IPROVENT OTRIVIN ADVANCE (in combination) OTRIVIN DUO (in combination)

Description

Ipratropium is a quaternary ammonium compound with anticholinergic (parasympatholytic) properties. Ipratropium appears to inhibit vagally mediated reflexes by antagonising the action of acetylcholine, the transmitter agent released from the vagus nerve. Anticholinergics prevent the increase in intracellular concentration of Ca++, which is caused by interaction of acetylcholine with the muscarinic receptor on bronchial smooth muscle. Ca++ release is mediated by the second messenger system consisting of IP3 (inositol triphosphate) and DAG (diacylglycerol).

ATC Classification

Code
Title
Category
R01AX03
Ipratropium bromide
R Respiratory system → R01 Nasal preparations → R01A Decongestants and other nasal preparations for topical use → R01AX Other nasal preparations
R03BB01
Ipratropium bromide
R Respiratory system → R03 Drugs for obstructive airway diseases → R03B Other drugs for obstructive airway diseases, inhalants → R03BB Anticholinergics

Related medicines

MPI, US: SPL/PLR 2020: ATROVENT HFA Inhalation aerosol, metered
MPI, EU: SmPC 2018: ATROVENT Nebuliser solution

2D Molecule Structure

Unique Ingredient Identifier (UNII)

J697UZ2A9J - IPRATROPIUM BROMIDE

CAS Registry Number

22254-24-6 - ipratropium bromide

SNOMED-CT

372518007 - Ipratropium (substance)

 
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