Ipratropium Other names: Ipratropium bromide

Chemical formula: C₂₀H₃₀BrNO₃  Molecular mass: 332.463 g/mol  PubChem compound: 657308

Active ingredient description

Ipratropium is a quaternary ammonium compound with anticholinergic (parasympatholytic) properties. Ipratropium appears to inhibit vagally mediated reflexes by antagonising the action of acetylcholine, the transmitter agent released from the vagus nerve. Anticholinergics prevent the increase in intracellular concentration of Ca++, which is caused by interaction of acetylcholine with the muscarinic receptor on bronchial smooth muscle. Ca++ release is mediated by the second messenger system consisting of IP3 (inositol triphosphate) and DAG (diacylglycerol).

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
R01AX03 Ipratropium bromide R Respiratory system → R01 Nasal preparations → R01A Decongestants and other nasal preparations for topical use → R01AX Other nasal preparations
Discover more medicines within R01AX03
R03BB01 Ipratropium bromide R Respiratory system → R03 Drugs for obstructive airway diseases → R03B Other drugs for obstructive airway diseases, inhalants → R03BB Anticholinergics
Discover more medicines within R03BB01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ATROVENT Nebuliser solution Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
ATROVENT HFA Inhalation aerosol, metered FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 22254-24-6
DrugBank Drug: DB00332
PubChem Compound: 657308
SNOMED-CT Concept: 372518007
Ipratropium (substance)
UNII Identifier: GR88G0I6UL
IPRATROPIUM

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