Source: Health Products Regulatory Authority (ZA) Revision Year: 2025 Publisher: Austell Pharmaceuticals (Pty) Ltd., 1 Sherborne Road, Parktown, Johannesburg, 2193, South Africa, Tel: +27 11 611 1400 or +27 860 287 835
Pharmacological Classification/Category and Class: A 3.1 Antirheumatics (Anti-inflammatory agents)
Pharmacotherapeutic group: Propionic acid derivatives.
ATC Code: M01AE01
Ibuprofen has analgesic, antipyretic and anti-inflammatory activities. Its analgesic activity is exerted through a peripheral action of blocking pain-impulse generation. The peripheral action of ibuprofen may also be due to inhibition of prostaglandin synthesis or to inhibition of the synthesis or actions of other substances that sensitize pain receptors to mechanical or chemical stimulation. Ibuprofen exerts its antipyretic effects by acting centrally on the hypothalamic heat-regulating centre to produce peripheral vasodilation resulting in increased blood flow through the skin, sweating and heat loss.
Ibuprofen exerts its anti-inflammatory action peripherally in inflamed tissue by reducing prostaglandin activity and by inhibiting synthesis and/or actions of other local mediators of the inflammatory response.
Rapidly absorbed after oral administration. Onset of action for pain relief is 30 minutes and the time for peak effect for fever is 2 to 4 hours. The half-life of Ibuprofen is about 2 hours and the duration of action for fever is 6 to 8 hours or more and is 4 to 6 hours for pain. The excretion of ibuprofen is rapid and complete with more than 90% of an ingested dose excreted in the urine as metabolites or their conjugates.
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