Source: Registered Drug Product Database (NG) Publisher: Bond chemical Industries Limited, Plot 20–26 Adesakin Layout, Awe, Oyo State, Nigeria
Pharmacotherapeutic group: Other analgesics and antipyretics, Anilides
ATC code: N02BE01
Paracetamol has analgesic and antipyretic properties but it has no useful anti-inflammatory properties.
Paracetamol’s effects are thought to be related to inhibition of prostaglandin synthesis.
Paracetamol is readily absorbed from the gastrointestinal tract.
Peak plasma concentrations occur about 10 to 60 minutes after oral doses. Paracetamol is distributed into most body tissues. It crosses the placenta and is present in breast milk. Plasma-protein binding is negligible at usual therapeutic concentrations but increases with increasing concentrations.
It is metabolised in the liver. A minor hydroxylated metabolite which is usually produced in very small amounts by mixed-function oxidases in the liver and which is usually detoxified by conjugation with liver glutathione may accumulate following paracetamol overdosage and cause tissue damage.
It is excreted in the urine, mainly as the glucuronide and sulfate conjugates. The elimination half-life varies from about 1 to 4 hours.
Conventional studies using the currently accepted standards for the evaluation of toxicity to reproduction and development are not available.
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