Active ingredients: Clodronic acid
Bonefos 800 mg tablets.
Pale white, oval-shaped, film-coated tablets for oral use.
Each tablet contains 1000 mg of disodium clodronate tetrahydrate, equivalent to 800 mg of anhydrous disodium clodronate.
For the full list of excipients, see section 6.1.
Clodronic acid is a bisphosphonate, (formerly diphosphonates), a group of analogues of pyrophosphate, which have been shown, in vitro, to inhibit the formation and dissolution of calcium phosphate (hydroxyapatite). In vivo, they have been shown to inhibit bone resorption to a greater or lesser extent, depending on the compound, and clodronate is one of the most effective in this respect.
Silicified microcrystalline cellulose
Opadry II white, containing:
Macrogol (PEG) 3350
Polyvinyl alcohol (partially hydrolysed)
Titanium dioxide (E171)
Bonefos tablets are supplied in clear, colourless PVC/aluminium blister packs of 10 and 60 tablets.
Not all pack sizes may be marketed.
Bayer plc, 400 South Oak Way, Reading, RG2 6AD
01 May 2008