Chemical formula: CH₄Cl₂O₆P₂ Molecular mass: 244.892 g/mol PubChem compound: 25419
Clodronic acid is a bisphosphonate, (formerly diphosphonates), a group of analogues of pyrophosphate, which have been shown, in vitro, to inhibit the formation and dissolution of calcium phosphate (hydroxyapatite). In vivo, they have been shown to inhibit bone resorption to a greater or lesser extent, depending on the compound, and clodronate is one of the most effective in this respect.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| M05BA02 | Clodronic acid | M Musculo-skeletal system → M05 Drugs for treatment of bone diseases → M05B Drugs affecting bone structure and mineralization → M05BA Bisphosphonates |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| BONEFOS Film-coated tablets | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Clodronic acid is an active ingredient of these brands:
Austria (AT)
Brazil (BR)Canada (CA)
Finland (FI)Germany (DE)
Hong Kong (HK)Israel (IL)
Italy (IT)
Malta (MT)
Romania (RO)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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