Source: Υπουργείο Υγείας (CY) Revision Year: 2014 Publisher: Medochemie Ltd, 1-10 Constantinopoleos Street, 3011 Limassol, Cyprus
Pharmacotherapeutic group: Other peripheral vasodilators, Cardiovascular system
ATC code: C04AX21
Naftidrofuryl oxalate is a powerful spasmolytic agent. It also has a direct effect on intracellular metabolism. It produces an increase of ATP levels and a decrease of lactic acid levels in ischaemic conditions evidence for an enhancement of cellular oxidative capacity.
Naftidrofuryl oxalate is well absorbed when given orally. Peak plasma levels occur about 30 minutes after dosing and the half-life is about an hour although inter subject variation is relatively high. Accumulation does not occur at a dose level of 200mg three times daily.
The drug becomes extensively bound to plasma proteins and is excreted principally via the urine, all in the form of metabolites.
In animal studies no toxic effects were seen. In repeated dose studies the no effect level was 25 mg/kg/day or greater. There was no evidence of effects on reproduction below doses which caused maternal toxicity.
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