Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2018 Publisher: Mylan Products Ltd, Station Close, Potters Bar, Hertfordshire, EN6 1TL, United Kingdom
For treatment of hypertension, either alone or as an adjunct to treatment with anti-hypertensive drugs.
For use as a diuretic.
1 tablet (20 mg) daily, as a single early morning dose. When using Diurexan in combination with other antihypertensive therapy, the same dose of 20 mg as a single early morning dose should be maintained.
No dose recommended.
See ‘Precautions’.
In the initial phase of treatment the usual dose is 2 tablets (40 mg) daily in a single early morning dose. Depending on the patient’s response, the dose may be lowered to 1 tablet daily when sufficient control of oedema has been achieved. Higher doses, up to 4 tablets daily (80 mg), may be employed in resistant cases.
No dose recommended.
See ‘Precautions’.
There is no specific antidote to xipamide. Acute intoxications express themselves especially with disturbances in the electrolytes and fluid balance (hyponatraemia, hypokalaemia). Clinical symptoms such as nausea, vomiting, drop in blood pressure, convulsions, dizziness, somnolence, confusional state, polyuria or oliguria and anuria (due to hypovolaemia) may occur.
Emergency procedures: detoxification by administering activated charcoal; subsequently restoration of a normal water and electrolytes balance in a specialized centre.
Gastric lavage or induced emesis may prevent further absorption. General measures should be aimed at the maintenance of blood pressure, restoration of blood volume and correction of electrolyte imbalance with appropriate intravenous infusion as required.
5 years.
None.
Aluminium – PVC Blister strip holds 14 tablets Ten blister strips in folded cardboard box.
Not relevant.
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