Source: Health Products Regulatory Authority (IE) Revision Year: 2019 Publisher: Rowex Ltd, Newtown, Bantry, Co. Cork, Ireland
ENAP 5mg Tablets.
| Pharmaceutical Form |
|---|
|
Tablet. White oblong tablets with EN 5' embossed and a break notch on one side. The tablets can be divided into equal halves. |
Each tablet contains 5mg enalapril maleate.
Excipients with known effect: Each tablet contains 129.8mg lactose monohydrate and 0.712mg sodium.
For the full list of excipients, see section 6.1.
| Active Ingredient | Description | |
|---|---|---|
| Enalapril |
Enalapril is hydrolysed via hepatic CES 1 to the active metabolite enalaprilat, which acts as an ACE inhibitor. ACE is a peptidyl dipeptidase which catalyses the conversion of angiotensin I to the vasoconstrictor substance angiotensin II and hence inhibition of ACE results in decreased plasma angiotensin II. This also leads to increased plasma renin activity and decreased aldosterone secretion. The mechanism of action of enalapril is therefore primarily via the suppression of the RAAS. However, ACE is identical to kininase II, and so enalapril may also exert its effects by blocking the degradation of bradykinin, a potent vasodepressor peptide. |
| List of Excipients |
|---|
|
Sodium hydrogen carbonate |
ENAP 5mg Tablets are packed in blisters of aluminium – aluminium welded on an internally varnished aluminium support.
ENAP 5mg Tablets are available in pack sizes of 30 tablets and 50 tablets.
Not all pack sizes may be marketed.
Rowex Ltd, Newtown, Bantry, Co. Cork, Ireland
PA0711/028/001
Date of first authorisation: 26 November 1999
Date of last renewal: 26 November 2009
| Drug | Countries | |
|---|---|---|
| ENAP | Albania, Estonia, Hong Kong, Croatia, Ireland, Lithuania, Poland, Romania, Singapore, South Africa |
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