Source: Υπουργείο Υγείας (CY) Revision Year: 2016 Publisher: Remedica Ltd, Aharnon Str.,Limassol Industrial Estate, 3056 Limassol, Cyprus
Pharmacotherapeutic group: Drugs used in diabetes; Blood glucose lowering drugs, excl. insulins
ATC Code: A10BB01
The pharmacodynamic effect of glibenclamide is to lower blood glucose levels.
Mechanisms proposed for this effect include:
Plasma glucose levels affect the insulin-releasing response to glibenclamide, (a high glucose level increases the response). The minimum active concentration for effect is considered to be 30–50 nanograms/ml glibenclamide.
Investigations of the relationship between insulin, glucose levels and glibenclamide in the hypoglycaemic effect continue.
A sulphonylurea hypoglycaemic agent rapidly absorbed and inducing its effect within 3 hours with a duration of up to 15 hours although the T½ of drug is 5 to 10 hours. The drug is metabolised extensively in the liver and excreted via bile and urine. It is strongly protein-bound.
None of clinical relevance.
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