Glibenclamide Other names: Glyburide

Chemical formula: C₂₃H₂₈ClN₃O₅S  Molecular mass: 494.004 g/mol  PubChem compound: 3488

Active ingredient description

Glibenclamide, a second-generation, short half-life sulphonylurea, is a hypoglycaemic agent that reduces blood-glucose by stimulating insulin release by the pancreas. Sulphonylureas act on pancreatic beta-cells by inhibiting ATP-sensitive potassium channels.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
A10BB01 Glibenclamide A Alimentary tract and metabolism → A10 Drugs used in diabetes → A10B Blood glucose lowering drugs, excl. insulins → A10BB Sulfonamides, urea derivatives
Discover more medicines within A10BB01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
AMGLIDIA Oral suspension European Medicines Agency (EU) MPI, EU: SmPC
GLIBESYN Tablet Υπουργείο Υγείας (CY) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

3D molecular structure

3D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 10238-21-8
DrugBank Drug: DB01016
KEGG Drug: D00336
PubChem Compound: 3488
RxNorm Ingredient: 4815
SNOMED-CT Concept: 384978002
Glibenclamide (substance)
UNII Identifier: SX6K58TVWC
GLYBURIDE

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