Glibenclamide Other names: Glyburide

Chemical formula: C₂₃H₂₈ClN₃O₅S Molecular mass: 494.004 g/mol PubChem compound: 3488

Therapeutic indications

Glibenclamide is indicated for:

Diabetes mellitus

Population group: only adults (18 years old or older)

Glibenclamide is is a sulphonylurea hypoglycaemic agent, indicated for the oral treatment of patients with non-insulin dependent diabetes who respond inadequately to dietary measures alone.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

2.5-5 mg once daily and thereafter 2.5-15 mg daily

Neonatal diabetes mellitus

Population group: only newborns (0 - 40 days old) , infants (40 days - 1 year old) , children (1 year - 12 years old)

Glibenclamide is indicated for the treatment of neonatal diabetes mellitus, for use in newborns, infants and children.

Sulphonylureas like glibenclamide have been shown to be effective in patients with mutations in the genes coding for the β-cell ATP-sensitive potassium channel and chromosome 6q24-related transient neonatal diabetes mellitus.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

0.2 mg/kg per day in 2 divided doses and then increase by 0.2 mg/kg/day until insulin independence is achieved

Contraindications

Glibenclamide is contraindicated in the following cases:

Severe hepatic impairment

Hepatic failure stage IV

Pregnancy

Lactation

Ketoacidosis

Porphyria

Bosentan

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Diabetes mellitus type 1

Diabetes mellitus type I

Diabetic coma or precoma

Coma due to diabetes mellitus

Serious impairment of adrenocortical function

Adrenal cortical hypofunction

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