Leading the way to safer medication
 Crosscheck  Recommender

ATC Group: A10BB Sulfonamides, urea derivatives

Anatomical Therapeutic Chemical Classification System

Hierarchical Position

Level
Code
Title
1
A
Alimentary tract and metabolism
2
A10
Drugs used in diabetes
3
A10B
Blood glucose lowering drugs, excl. insulins
4
A10BB
Sulfonamides, urea derivatives

Contents

Code
Title
A10BB01
Glibenclamide
A10BB02
Chlorpropamide
A10BB03
Tolbutamide
A10BB04
Glibornuride
A10BB05
Tolazamide
A10BB06
Carbutamide
A10BB07
Glipizide
A10BB08
Gliquidone
A10BB09
Gliclazide
A10BB10
Metahexamide
A10BB11
Glisoxepide
A10BB12
Glimepiride
A10BB31
Acetohexamide

Active Ingredients

Chemical substance
Description
Chlorpropamide

Chlorpropamide is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. It appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. The mechanism by which chlorpropamide lowers blood glucose during long-term administration has not been clearly established.

Glibenclamide

Glibenclamide, a second-generation, short half-life sulphonylurea, is a hypoglycaemic agent that reduces blood-glucose by stimulating insulin release by the pancreas.

Gliclazide

Gliclazide is a hypoglycaemic sulfonylurea antidiabetic active substance. Gliclazide reduces blood glucose levels by stimulating insulin secretion from the β-cells of the islets of Langerhans.

Glimepiride

Glimepiride is an orally active hypoglycaemic substance belonging to the sulphonylurea group. It may be used in non-insulin dependent (type 2) diabetes mellitus. Glimepiride acts mainly by stimulating insulin release from pancreatic beta cells.

Glipizide

Glipizide is an oral blood-glucose-lowering drug of the sulfonylurea class. The primary mode of action of glipizide is the stimulation of insulin secretion from the beta-cells of pancreatic islet tissue.

Gliquidone

Gliquidone is an anti-diabetic drug in the sulfonylurea class. It is used in the treatment of diabetes mellitus type 2. It is an ATP-dependent K+ (KATP) channel blocker. This block causes a depolarization which leads to activation of voltage-dependent Ca channels and Ca2+ influx, and eventually increases insulin release.

Tolbutamide

Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin.

Monographs

Monograph
Type
Country
AMARYL Tablet
MPI, US: SPL/PLR
US
AMGLIDIA Oral suspension
MPI, EU: SmPC
UK
GLICLAZIDE Tablets
MPI, EU: SmPC
UK
GLUCOTROL Tablet
MPI, US: SPL/Old
US
GLUCOTROL XL Extended-release tablet
MPI, US: SPL/PLR
US