HISTERGAN Topical cream Ref.[27732] Active ingredients: Diphenhydramine

Source: Medicines & Healthcare Products Regulatory Agency (GB)  Revision Year: 2017  Publisher: Norma Chemicals Ltd., 51-53 Stert Street, Abingdon, Oxfordshire OX14 3JF United Kingdom

5.1. Pharmacodynamic properties

Diphenhydramine applied externally has anti-histaminic activity in conditions induced by allergic stimuli.

5.2. Pharmacokinetic properties

Diphenhydramine is a histamine H1 receptor antagonist.

External applications to largely intact skin results in minimal systemic absorption.

5.3. Preclinical safety data

None stated.

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