Chemical formula: C₁₇H₂₁NO Molecular mass: 255.355 g/mol PubChem compound: 3100
Diphenhydramine is an ethanolamine-derivative antihistamine. It is an antihistamine with anticholinergic and marked sedative effects. It acts by inhibiting the effects on H1-receptors. Diphenhydramine is effective in reducing sleep onset (i.e., time to fall asleep) and increasing the depth and quality of sleep.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| D04AA32 | Diphenhydramine | D Dermatologicals → D04 Antipruritics, incl. antihistamines, anesthetics, etc. → D04A Antipruritics, incl. antihistamines, anesthetics, etc. → D04AA Antihistamines for topical use |
| R06AA02 | Diphenhydramine | R Respiratory system → R06 Antihistamines for systemic use → R06A Antihistamines for systemic use → R06AA Aminoalkyl ethers |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| BELARMIN Syrup | Υπουργείο Υγείας (CY) | MPI, EU: SmPC | |
| NYTOL ONE-A-NIGHT Tablet Diphenhydramine | Health Products Regulatory Authority (IE) | MPI, EU: SmPC | |
| DIPHEN Oral solution | FDA, National Drug Code (US) | MPI, US: SPL/Old |
Diphenhydramine is an active ingredient of these brands:
Austria (AT)
Brazil (BR)Canada (CA)
Croatia (HR)Cyprus (CY)
Ecuador (EC)
France (FR)
Germany (DE)
Hong Kong (HK)
Ireland (IE)Israel (IL)
Japan (JP)
Lithuania (LT)Malta (MT)
Mexico (MX)
New Zealand (NZ)
Nigeria (NG)
Poland (PL)
Romania (RO)Singapore (SG)
South Africa (ZA)
Spain (ES)
Tunisia (TN)
Turkey (TR)
United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.
