Active ingredients: Azathioprine
Imuran Tablets 25 mg.
Tablet.
Orange, round, biconvex, film-coated tablets, unscored, branded ‘IM 2’ and containing 25 mg Azathioprine BP in each tablet
Each tablet contains 25 mg of the active substance azathioprine.
Excipient(s) with known effect: Each 25 mg tablet contains 37 mg lactose monohydrate.
For the full list of excipients, see section 6.1.
Azathioprine is a pro-drug of 6-mercaptopurine (6-MP). 6-MP is inactive but acts as a purine antagonist and requires cellular uptake and intracellular anabolism to thioguanine nucleotides (TGNs) for immunosuppression. The TGNs and other metabolites (e.g. 6-methyl-mecaptopurine ribonucleotides) inhibit de novo purine synthesis and purine nucleotide interconversions.
Lactose
Pregelatinised starch
Maize starch
Stearic acid
Magnesium stearate
Methylhydroxylpropyl cellulose
Polyethylene glycol 400
Titanium dioxide (E171)
Iron oxide, yellow (E172)
Iron oxide, red (E172)
Blister strips in a pack.
Pack sizes: 28, 30, 56, 60 and 100 tablets.
Aspen Pharma Trading Limited, 3016 Lake Drive, Citywest Business Campus, Dublin 24, Ireland
PL 39699/0004
20 March 1992