Azathioprine

Active ingredient description

Azathioprine is a pro-drug of 6-mercaptopurine (6-MP). 6-MP is inactive but acts as a purine antagonist and requires cellular uptake and intracellular anabolism to thioguanine nucleotides (TGNs) for immunosuppression. The TGNs and other metabolites (e.g. 6-methyl-mecaptopurine ribonucleotides) inhibit de novo purine synthesis and purine nucleotide interconversions.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
Azathioprine
L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AX Other immunosuppressants
Discover more medicines within L04AX01

Medicines

Azathioprine is the active ingredient of these drugs:

Drug
Countries

Lithuania

Germany

Austria Germany Lithuania

Singapore

Hong Kong

United Kingdom

United States

Australia

Spain

Austria

Ireland

Brazil

Cyprus Hong Kong

Australia Brazil Canada Cyprus Hong Kong

Austria Germany Tunisia

France Germany Spain Tunisia

Brazil

Ireland Lithuania

Product monographs

Medicine agencies around the world have authorized marketing of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Summary of product characteristics (SPC)
UK
Summary of product characteristics (SPC)
CY
Summary of product characteristics (SPC)
UK

Structural formula

Graphic representation of the active ingredient's molecular structure

3D molecular structure

3D representation of the active ingredient's molecular structure

Unique ingredient identifier (UNII)

MRK240IY2L - AZATHIOPRINE

CAS registry number

446-86-6 - azathioprine

SNOMED-CT

372574004 - Azathioprine (substance)