Azathioprine
Description
Azathioprine is a pro-drug of 6-mercaptopurine (6-MP). 6-MP is inactive but acts as a purine antagonist and requires cellular uptake and intracellular anabolism to thioguanine nucleotides (TGNs) for immunosuppression. The TGNs and other metabolites (e.g. 6-methyl-mecaptopurine ribonucleotides) inhibit de novo purine synthesis and purine nucleotide interconversions.
ATC Classification
Trade names
Austria
Singapore
United States
Australia
Austria
Cyprus
Australia Canada Cyprus Netherlands Singapore
Austria
France
Product Monographs
2D Molecule Structure
3D Molecule Structure
Unique Ingredient Identifier (UNII)
MRK240IY2L - AZATHIOPRINE
CAS Registry Number
446-86-6 - azathioprine
SNOMED-CT
372574004 - Azathioprine (substance)