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Azathioprine

Description

Azathioprine is a pro-drug of 6-mercaptopurine (6-MP). 6-MP is inactive but acts as a purine antagonist and requires cellular uptake and intracellular anabolism to thioguanine nucleotides (TGNs) for immunosuppression. The TGNs and other metabolites (e.g. 6-methyl-mecaptopurine ribonucleotides) inhibit de novo purine synthesis and purine nucleotide interconversions.

ATC Classification

Code
Title
Category
L04AX01
Azathioprine
L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AX Other immunosuppressants

Trade names

Trade name
Countries
AZAFALK

Austria

AZAFRINE

Singapore

AZAPRESS

United Kingdom

AZASAN

United States

IMAZAN

Australia

IMMUFALK

Spain

IMMUNOPRIN

Austria

IMUPRIN

Cyprus

IMURAN

Australia Canada Cyprus Netherlands Singapore

IMUREK

Austria

IMUREL

France Spain

Product Monographs

Monograph
Type
Country
Imuran Tablets 25mg
MPI, EU: SmPC
UK
AZATHIOPRINE / SANDOZ Film-coated tablets
MPI, EU: SmPC
UK

2D Molecule Structure

3D Molecule Structure

Unique Ingredient Identifier (UNII)

MRK240IY2L - AZATHIOPRINE

CAS Registry Number

446-86-6 - azathioprine

SNOMED-CT

372574004 - Azathioprine (substance)

 
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