Chemical formula: C₉H₇N₇O₂S Molecular mass: 277.263 g/mol PubChem compound: 2265
Azathioprine is a pro-drug of 6-mercaptopurine (6-MP). 6-MP is inactive but acts as a purine antagonist and requires cellular uptake and intracellular anabolism to thioguanine nucleotides (TGNs) for immunosuppression. The TGNs and other metabolites (e.g. 6-methyl-mecaptopurine ribonucleotides) inhibit de novo purine synthesis and purine nucleotide interconversions.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
ATC code | Group title | Classification |
---|---|---|
L04AX01 | Azathioprine | L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AX Other immunosuppressants |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
Title | Information Source | Document Type | |
---|---|---|---|
IMURAN Tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
IMUPRIN Film-coated tablet | Υπουργείο Υγείας (CY) | MPI, EU: SmPC | |
AZATHIOPRINE / SANDOZ Film-coated tablets | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Azathioprine is an active ingredient of these brands:
Austria (AT)Brazil (BR)Canada (CA)Estonia (EE)Finland (FI)France (FR)Israel (IL)Mexico (MX)Netherlands (NL)Romania (RO)Turkey (TR)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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