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Azathioprine

Description

Azathioprine is a pro-drug of 6-mercaptopurine (6-MP). 6-MP is inactive but acts as a purine antagonist and requires cellular uptake and intracellular anabolism to thioguanine nucleotides (TGNs) for immunosuppression. The TGNs and other metabolites (e.g. 6-methyl-mecaptopurine ribonucleotides) inhibit de novo purine synthesis and purine nucleotide interconversions.

ATC Classification

Code
Title
Category
L04AX01
Azathioprine
L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AX Other immunosuppressants

Trade names

Trade name
Countries

Austria

Singapore

United States

Australia

Austria

Cyprus

Australia Canada Cyprus Netherlands Singapore

Austria

France

Product Monographs

Monograph
Type
Country
Imuran Tablets 25mg
MPI, EU: SmPC
UK
AZATHIOPRINE / SANDOZ Film-coated tablets
MPI, EU: SmPC
UK