Active ingredients: Esomeprazole
Nexium 20 mg gastro-resistant tablets.
A light-pink, oblong, biconvex, film-coated tablet engraved 20 mg on one side and A / EH on the other side.
Each gastro-resistant tablet contains 22.3 mg esomeprazole magnesium trihydrate equivalent to 20 mg esomeprazole.
Excipient(s) with known effect: Each gastro-resistant tablet contains 28 mg sucrose.
For the full list of excipients, see section 6.1.
Esomeprazole is the S-isomer of omeprazole and reduces gastric acid secretion through a specific targeted mechanism of action. Esomeprazole is a weak base and is concentrated and converted to the active form in the highly acidic environment of the secretory canaliculi of the parietal cell, where it inhibits the enzyme H+ K+ -ATPase – the acid pump and inhibits both basal and stimulated acid secretion.
Glycerol monostearate 40-55
Iron oxide (reddish-brown and yellow) (E172)
Methacrylic acid ethyl acrylate copolymer (1:1) dispersion 30 per cent
Sodium stearyl fumarate
Sugar spheres (sucrose and maize starch)
Titanium dioxide (E171)
Blister packs in wallet and/or carton of 3, 7, 7x1, 14, 15, 25x1, 28, 30, 50x1, 56, 60, 90, 98, 100x1, 140 tablets.
Not all pack sizes may be marketed.
AstraZeneca UK Limited, 600 Capability Green, Luton, LU1 3LU, UK
Date of first authorisation: 10 March 2005
Date of latest renewal: 10 March 2010