OPDIVO Solution for injection Ref.[116349] Active ingredients:

Source: European Medicines Agency (EU)  Revision Year: 2026  Publisher: Bristol-Myers Squibb Pharma EEIG, Plaza 254, Blanchardstown Corporate Park 2, Dublin 15, D15 T867, Ireland

Product name and form

OPDIVO 600 mg solution for injection.

Pharmaceutical Form

Solution for injection.

Clear to opalescent, colourless to yellow liquid, essentially free of visible particulates. The solution has a pH of 5.5-6.5 and an osmolality of 296-444 mOsm/kg.

Qualitative and quantitative composition

Each mL of solution for injection contains 120 mg of nivolumab.

One vial of 5 mL contains 600 mg of nivolumab.

Nivolumab is produced in Chinese hamster ovary cells by recombinant DNA technology.

For the full list of excipients, see section 6.1.

Excipient with known effect:

Each 5 mL vial of this this medicinal product contains 2.5 mg of polysorbate 80.

List of Excipients

Recombinant human hyaluronidase (rHuPH20)
Histidine
Histidine hydrochloride monohydrate
Sucrose
Pentetic acid
Polysorbate 80 (E433)
Methionine
Water for injection

Pack sizes and marketing

Type I glass vial with a butyl rubber stopper and an aluminium seal with a plastic orange flip-off cap containing 5 mL of solution for injection.

Pack of one vial.

Marketing authorization holder

Bristol-Myers Squibb Pharma EEIG, Plaza 254, Blanchardstown Corporate Park 2, Dublin 15, D15 T867, Ireland

Marketing authorization dates and numbers

EU/1/15/1014/005

Date of first authorisation: 19 June 2015
Date of latest renewal: 23 April 2020

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