Source: Registered Drug Product Database (NG) Revision Year: 2025
PAWAFENAC
(DICLOFENAC POTASSIUM TABLETS 50)
| Pharmaceutical Form |
|---|
|
Tablet. |
| Sr. No. | Ingredients | Spec | Qty/ Tab (mg) | Ovg. (%) |
|---|---|---|---|---|
| 1 | Diclofenac Potassium | BP | 50.00 | -- |
| 2 | *Maize Starch | BP | 319.35 | -- |
| 3 | Dicalcium Phosphate | BP | 181.00 | -- |
| 4 | *Maize Starch (P) | BP | 25.00 | -- |
| 5 | Microcrystalline Cellulose | BP | 136.00 | -- |
| 6 | Methyl Paraben | BP | 1.50 | -- |
| 7 | Propyl Paraben | BP | 0.15 | -- |
| LUBRICANTS | ||||
| 9 | Purified Talc | BP | 10.00 | -- |
| 10 | Colloidal Silicon Dioxide | BP | 5.00 | -- |
| 11 | Magnesium Stearate | BP | 7.00 | -- |
| 12 | Sodium starch glycolate | BP | 15.00 | -- |
| 13 | *Maize Starch (Additional) | BP | 32.64 | -- |
| TOTAL | 750 mg | |||
| FILM COATING | ||||
| 14 | Readycoat AMB Green colour | IH | 14.50 | -- |
| 15 | Purified Talc | BP | 2.50 | -- |
| 16 | Purified water | IH | QS | -- |
| TOTAL | 767.00 mg | |||
* Additional Maize starch is added to compensate the loss on drying.
BP: British Pharmacopoeia
IH: In-House Specification
Average weight of uncoated tablet: 750 mg ± 5%
Average weight of film-coated tablet: 757 mg ± 5%
| Active Ingredient |
|---|
|
Diclofenac is a non-steroidal anti-inflammatory drug. The mechanism of action of diclofenac in AK may be related to the inhibition of the cycloxygenase pathway leading to reduced prostaglandin E2 (PGE2) synthesis. In addition, immunohistochemistry (IHC) from skin biopsies ac revealed that the clinical effects of diclofenac in AK are primarily due to anti-inflammatory, anti-angiogenic and possibly anti-proliferative effects and apoptosis-inducing mechanisms. |
| List of Excipients | ||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Blister pack of 1 x 10 tablets.
| Drug | Countries | |
|---|---|---|
| PAWAFENAC | Nigeria |
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