Diclofenac Other names: Diclofenac sodium

Chemical formula: C₁₄H₁₁Cl₂NO₂  Molecular mass: 296.149 g/mol  PubChem compound: 3033

Active ingredient description

Diclofenac is a non-steroidal anti-inflammatory drug. The mechanism of action of diclofenac in AK may be related to the inhibition of the cycloxygenase pathway leading to reduced prostaglandin E2 (PGE2) synthesis. In addition, immunohistochemistry (IHC) from skin biopsies ac revealed that the clinical effects of diclofenac in AK are primarily due to anti-inflammatory, anti-angiogenic and possibly anti-proliferative effects and apoptosis-inducing mechanisms.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
D11AX18 Diclofenac D Dermatologicals → D11 Other dermatological preparations → D11A Other dermatological preparations → D11AX Other dermatologicals
Discover more medicines within D11AX18
M01AB05 Diclofenac M Musculo-skeletal system → M01 Antiinflammatory and antirheumatic products → M01A Antiinflammatory and antirheumatic products, non-steroids → M01AB Acetic acid derivatives and related substances
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M02AA15 Diclofenac M Musculo-skeletal system → M02 Topical products for joint and muscular pain → M02A Topical products for joint and muscular pain → M02AA Antiinflammatory preparations, non-steroids for topical use
Discover more medicines within M02AA15
S01BC03 Diclofenac S Sensory organs → S01 Ophthalmologicals → S01B Antiinflammatory agents → S01BC Antiinflammatory agents, non-steroids
Discover more medicines within S01BC03

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
CAMBIA Powder for oral solution FDA, National Drug Code (US) MPI, US: SPL/PLR
VOLTAROL RAPID Coated tablet Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
DICLODENT Oromucosal solution (Mouthwash) Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
VOLTAROL PAIN-EZE EMULGEL Gel for topical administration Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
VOLTAROL Medicated Plaster Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
FLECTOR Patch FDA, National Drug Code (US) MPI, US: SPL/PLR
VOLTAROL OPTHA MULTIDOSE Eye drops solution Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
SOLARAZE Gel Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
AKIS Solution for injection Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
VOLTAROL Suppositories Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

3D molecular structure

3D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 15307-79-6
CAS Substance: 15307-86-5
CAS Substance: 78213-16-8
DrugBank Drug: DB00586
KEGG Drug: D07816
PubChem Compound: 3033
RxNorm Ingredient: 3355
SNOMED-CT Concept: 7034005
Diclofenac (substance)
UNII Identifier: 144O8QL0L1
DICLOFENAC

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