Diclofenac Other names: Diclofenac sodium
Chemical formula: C₁₄H₁₁Cl₂NO₂ Molecular mass: 296.149 g/mol PubChem compound: 3033
Active ingredient description
Diclofenac is a non-steroidal anti-inflammatory drug. The mechanism of action of diclofenac in AK may be related to the inhibition of the cycloxygenase pathway leading to reduced prostaglandin E2 (PGE2) synthesis. In addition, immunohistochemistry (IHC) from skin biopsies ac revealed that the clinical effects of diclofenac in AK are primarily due to anti-inflammatory, anti-angiogenic and possibly anti-proliferative effects and apoptosis-inducing mechanisms.
Medicine classification
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC Group | Classification | |
|---|---|---|
| D11AX18 | Diclofenac | D Dermatologicals → D11 Other dermatological preparations → D11A Other dermatological preparations → D11AX Other dermatologicals |
| M01AB05 | Diclofenac | M Musculo-skeletal system → M01 Antiinflammatory and antirheumatic products → M01A Antiinflammatory and antirheumatic products, non-steroids → M01AB Acetic acid derivatives and related substances |
| M02AA15 | Diclofenac | M Musculo-skeletal system → M02 Topical products for joint and muscular pain → M02A Topical products for joint and muscular pain → M02AA Antiinflammatory preparations, non-steroids for topical use |
| S01BC03 | Diclofenac | S Sensory organs → S01 Ophthalmologicals → S01B Antiinflammatory agents → S01BC Antiinflammatory agents, non-steroids |
Product monographs
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Document | Type | Information Source | |
|---|---|---|---|
| AKIS Solution for injection | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) | |
| FLECTOR Patch | MPI, US: SPL/PLR | FDA, National Drug Code (US) | |
| VOLTAROL RAPID Coated tablet | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) | |
| CAMBIA Powder for oral solution | MPI, US: SPL/PLR | FDA, National Drug Code (US) | |
| VOLTAROL OPTHA MULTIDOSE Eye drops solution | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) | |
| VOLTAROL PAIN-EZE EMULGEL Gel for topical administration | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) | |
| SOLARAZE Gel | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) | |
| DICLODENT Oromucosal solution (Mouthwash) | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) | |
| VOLTAROL Medicated Plaster | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) | |
| VOLTAROL Suppositories | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) |
Structural formula
3D molecular structure
External identifiers
Medicines
Diclofenac is an active ingredient of these brands:
Albania (AL)Australia (AU)Austria (AT)
Brazil (BR)
Canada (CA)
Croatia (HR)
Cyprus (CY)
Ecuador (EC)
Estonia (EE)
Finland (FI)
France (FR)
Germany (DE)
Hong Kong (HK)
Ireland (IE)
Israel (IL)
Italy (IT)
Japan (JP)
Lithuania (LT)
Malta (MT)
Mexico (MX)
Netherlands (NL)
New Zealand (NZ)
Nigeria (NG)
Poland (PL)
Romania (RO)
Singapore (SG)
South Africa (ZA)
Spain (ES)
Tunisia (TN)
Turkey (TR)
United Kingdom (UK)
United States (US)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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