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ATC Group: M01AB Acetic acid derivatives and related substances

Anatomical Therapeutic Chemical Classification System

Translations

Language
Translation
  English
Acetic acid derivatives and related substances

Hierarchical Position

Level
Code
Title
4
M01AB
Acetic acid derivatives and related substances

Contents

Code
Title
M01AB01
M01AB02
M01AB03
M01AB04
M01AB05
M01AB06
M01AB07
M01AB08
M01AB09
M01AB10
M01AB11
M01AB12
M01AB13
M01AB14
M01AB15
M01AB16
M01AB17

Active Ingredients

Chemical substance
Description

Aceclofenac is a non-steroidal agent with marked anti-inflammatory and analgesic properties. The mode of action of aceclofenac is largely based on the inhibition to prostaglandin synthesis. Aceclofenac is a potent inhibitor of the enzyme cyclo-oxygenase, which is involved in the production of prostaglandins.

Acemetacin is a glycolic acid ester of indomethacin and the pharmacological activity resulting from acemetacin administration in man is derived from the presence of both acemetacin and indomethacin. The precise pharmacological mode of action of acemetacin is not known. However, unlike other NSAIDs, acemetacin is only a relatively weak inhibitor of prostaglandin synthetase.

Diclofenac is a non-steroidal anti-inflammatory drug. The mechanism of action of diclofenac in AK may be related to the inhibition of the cycloxygenase pathway leading to reduced prostaglandin E2 (PGE2) synthesis. In addition, immunohistochemistry (IHC) from skin biopsies ac revealed that the clinical effects of diclofenac in AK are primarily due to anti-inflammatory, anti-angiogenic and possibly anti-proliferative effects and apoptosis-inducing mechanisms.

Indometacin has anti-inflammatory, antipyretic, and analgesic effects, it is an inhibitor of prostaglandin synthetase.

Ketorolac is a non-steroidal anti-inflammatory agent demonstrating analgesic and anti-inflammatory activity. Ketorolac inhibits the cyclo-oxygenase enzyme essential for biosynthesis of prostaglandins. Ketorolac has been shown to reduce prostaglandin levels in the aqueous humour after topical ophthalmic administration.

Sulindac is a fluorinated indene with a structural resemblance to indometacin. It has analgesic, anti-inflammatory and antipyretic actions.

Monographs

Monograph
Type
Country
MPI, EU: SmPC
UK
MPI, EU: SmPC
UK
MPI, EU: SmPC
UK
MPI, EU: SmPC
UK
MPI, EU: SmPC
UK