Acemetacin

Active ingredient description

Acemetacin is a glycolic acid ester of indomethacin and the pharmacological activity resulting from acemetacin administration in man is derived from the presence of both acemetacin and indomethacin. The precise pharmacological mode of action of acemetacin is not known. However, unlike other NSAIDs, acemetacin is only a relatively weak inhibitor of prostaglandin synthetase.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
M01AB11
Acemetacin
M Musculo-skeletal system → M01 Antiinflammatory and antirheumatic products → M01A Antiinflammatory and antirheumatic products, non-steroids → M01AB Acetic acid derivatives and related substances
Discover more medicines within M01AB11

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
EMFLEX Capsule
Summary of Product Characteristics (SPC)
UK

Medicines

Acemetacin is the active ingredient of these drugs:

Drug
Countries
RANTUDIL

Germany Mexico Poland

RHEUTROP

Austria

ZILOXICUM

Germany

Structural formula

Graphic representation of the active ingredient's molecular structure

Chemical formula: C₂₁H₁₈ClNO₆
Molecular mass: 415.83 g/mol

External identifiers

CAS Substance: 53164-05-9
DrugBank Drug: DB13783
KEGG Drug: D01582
PubChem Compound: 1981
RxNorm Ingredient: 16695
SNOMED-CT Concept: 391704009
Acemetacin (substance)
UNII Identifier: 5V141XK28X
ACEMETACIN
 
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