PERPHENAN Film coated tablet Ref.[8267] Active ingredients: Perphenazine

Revision Year: 2016  Publisher: Taro Pharmaceutical Industries Ltd, 14 Hakitor Street, Haifa Bay, 2624761

Pharmacodynamic properties

Perphenazine is a depressant which blocks dopamine receptors in the central nervous system.

Pharmacokinetic properties

Perphenazine is absorbed readily from the gastro-intestinal tract. It is distributed widely throughout the body, and crosses the placenta.

Perphenazine is metabolised extensively by sulphoxidaction, demethylation, hydroxylation, N-oxidation, glucuronic acid conjugation, and possible ring fission.

20 to 70% is excreted in the urine, very little is unchanged. 5% is excreted in the faeces.

Preclinical safety data

No further relevant data.

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