PLENAMINE Solution for injection Ref.[50764] Active ingredients: Alanine Arginine Aspartic acid Glutamic acid hydrochloride Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine

Source: FDA, National Drug Code (US)  Revision Year: 2022 

2. Clinical Pharmacology

Plenamine 15% Amino Acids Injection provides seventeen crystalline amino acids. This completely utilizable substrate promotes protein synthesis and wound healing and reduces the rate of protein catabolism.

A. Total Parenteral Nutrition (Central Infusion)

When enteral feeding is inadvisable, Plenamine 15% given by central venous infusion in combination with energy sources, vitamins, trace elements and electrolytes, will completely satisfy the requirements for weight maintenance or weight gain, depending upon the dose selected. The energy component in parenteral nutrition by central infusion may be derived solely from dextrose or may be provided by a combination of dextrose and intravenous fat emulsion. The addition of intravenous fat emulsion provides essential fatty acids and permits a dietary balance of fat and carbohydrate, at the same time offering the option of reducing the dextrose load and/or increasing the total caloric input. An adequate energy supply is essential for optimal utilization of amino acids.

B. Total Parenteral Nutrition (Peripheral Infusion)

Plenamine 15% can also be administered as part of a total parenteral nutrition program by peripheral vein when the enteral route is inadvisable and use of the central venous catheter is contraindicated.

Reduction of protein loss can be achieved by use of diluted Plenamine 15% in combination with dextrose or with dextrose and intravenous fat emulsion by peripheral infusion. Complete peripheral intravenous nutrition can be achieved in patients with low caloric requirements by a Plenamine 15% dextrose-fat regimen.

6.6. Carcinogenesis, Mutagenesis, Impairment of Fertility

Studies with Plenamine 15% have not been performed to evaluate carcinogenic potential, mutagenic potential, or effects on fertility.

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