Source: Health Products Regulatory Authority (IE) Revision Year: 2021 Publisher: Aspen Pharma Trading Limited, 3016 Lake Drive, Citywest Business Campus, Dublin 24, Ireland
Puri-Nethol 50 mg Tablets.
| Pharmaceutical Form |
|---|
|
Tablet. Pale yellow, round tablets, biconvex, scored on one side, engraved PT and 50 on either side of the scoreline and plain on the other side. The scoreline is only to facilitate breaking of the tablets for ease of swallowing and not to divide into equal doses. |
Each tablet contains 50 mg of the active substance mercaptopurine monohydrate.
Excipients with known effect: Each tablet contains 59mg of the excipient lactose monohydrate.
For the full list of excipients, see section 6.1.
| Active Ingredient | Description | |
|---|---|---|
| Mercaptopurine |
Mercaptopurine is an inactive pro-drug which acts as a purine antagonist but requires cellular uptake and intracellular anabolism to thioguanine nucleotides for cytotoxicity. The mercaptopurine metabolites inhibit de novo purine synthesis and purine nucleotide interconversions. The thioguanine nucleotides are also incorporated into nucleic acids and this contributes to the cytotoxic effects of the active substance. |
| List of Excipients |
|---|
|
Lactose monohydrate |
Amber glass bottle containing 25 tablets with a child resistant high density polyethylene/polypropylene closure with induction heat seal liners (IHS).
Aspen Pharma Trading Limited, 3016 Lake Drive, Citywest Business Campus, Dublin 24, Ireland
PA1691/009/001
Date of first authorisation: 1st April 1979
Date of last renewal: 1st April 2009
| Drug | Countries | |
|---|---|---|
| PURI-NETHOL | Austria, Estonia, Hong Kong, Ireland, Israel, Lithuania, Malta, Netherlands, New Zealand, Romania |
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