Chemical formula: Câ‚…Hâ‚„Nâ‚„S Molecular mass: 152.177 g/mol PubChem compound: 667490
Mercaptopurine is an inactive pro-drug which acts as a purine antagonist but requires cellular uptake and intracellular anabolism to thioguanine nucleotides for cytotoxicity. The mercaptopurine metabolites inhibit de novo purine synthesis and purine nucleotide interconversions. The thioguanine nucleotides are also incorporated into nucleic acids and this contributes to the cytotoxic effects of the active substance.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01BB02 | Mercaptopurine | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01B Antimetabolites → L01BB Purine analogues |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| XALUPRINE Oral suspension | European Medicines Agency (EU) | MPI, EU: SmPC |
Mercaptopurine is an active ingredient of these brands:
United States (US)Australia (AU)Austria (AT)
Brazil (BR)Canada (CA)Ecuador (EC)Estonia (EE)
Finland (FI)
France (FR)
Hong Kong (HK)Ireland (IE)
Israel (IL)Italy (IT)
Japan (JP)Lithuania (LT)
Malta (MT)Mexico (MX)Netherlands (NL)
New Zealand (NZ)Poland (PL)
Romania (RO)Singapore (SG)Tunisia (TN)Turkey (TR)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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