RIDAQ 25 mg / 50 mg Tablet Ref.[50697] Active ingredients: Hydrochlorothiazide

Source: Health Products Regulatory Authority (ZA)  Revision Year: 2023  Publisher: PHARMACARE LIMITED, Healthcare Park, Woodlands Drive, Woodmead; 2191

5.1. Pharmacodynamic properties

Category and Class: A 18.1 Diuretics
Pharmacotherapeutic group: Medicines acting on reno-urinary and genital system
ATC code: C03AA03

Mechanism of action

Hydrochlorothiazide is a diuretic which reduces the reabsorption of electrolytes from the renal tubules, thereby increasing the excretion of sodium, potassium and chloride ions, and consequently of water. It also slightly increases bicarbonate excretion without appreciable alteration of the acid-base balance or the pH of the urine. It has a lowering effect on the blood pressure and enhances the action of other hypotensive medicine such as guanethidine, methyldopa and rauwolfia alkaloids.

5.2. Pharmacokinetic properties

Absorption

Hydrochlorothiazide is absorbed from the gastrointestinal tract, distributed throughout the extracellular space and diffuses across the placenta.

Distribution

Hydrochlorothiazide is distributed throughout the extracellular space and diffuses across the placenta.

Biotransformation

Diuresis occurs in about two hours, reaches a maximum in about four hours, and lasts for about twelve hours. Tolerance does not develop, and therapeutic efficacy is maintained when it is administered over long periods, but patients may not respond if their glomerular filtration rate is markedly reduced.

Elimination

The route of elimination is via the kidneys.

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