Source: Health Products Regulatory Authority (ZA) Revision Year: 2018 Publisher: sanofi-aventis south africa (pty) ltd., 2 Bond Street, Midrand, South Africa, 1685
A 20.2.3 Tuberculostatic combinations
RIFAFOUR e-275 tablets is a combination of four first line agents used in the treatment of tuberculosis. Rifampicin is a semi-synthetic, broad-spectrum bactericidal antibiotic. Isoniazid is a synthetic, antitubercular agent which is bacteriostatic against semi-dormant bacilli and bactericidal against actively dividing mycobacteria. Pyrazinamide may be bactericidal or bacteriostatic, depending on its concentration and the susceptibility of the organism. Ethambutol is a synthetic, bacteriostatic antitubercular agent. All agents are readily absorbed following oral administration, with wide distribution to most tissues and fluids including cerebrospinal fluid.
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