Active ingredients: Acenocoumarol
Sinthrome Tablets 1mg.
Tablets for oral administration.
White, round, flat tablets with slightly bevelled edges, with one side bearing the imprint “CG”, and the other the imprint “AA”.
Acenocoumarol BP 1mg.
Excipient(s) with known effect: Lactose (20 mg).
For the full list of excipients, see Section 6.1.
Acenocoumarol is a derivative of coumarin used as anticoagulant because acts as an antagonist of vitamin K. Vitamin K antagonists produce their anticoagulant effect by inhibition of the vitamin K-epoxide-reductase with a subsequent reduction of the gammacarboxylation of certain glutamic acid molecules which are located at several sites near the terminal end both of coagulation factors II (prothrombin), VII, IX, and X and of protein C or its cofactor protein S.
Aerosil 200 (silica aerogel)
Blister packs of 100 tablets.
Norgine Pharmaceuticals Limited, Norgine House, Widewater Place, Moorhall Road, Harefield, Uxbridge, UB9 6NS, UK
Date of first authorisation: 08 August 1972
Date of latest renewal: 25 February 2005