SLENYTO Prolonged-release tablet Ref.[115048] Active ingredients: Melatonin

Source: European Medicines Agency (EU)  Revision Year: 2025  Publisher: RAD Neurim Pharmaceuticals EEC SARL, 4 rue de Marivaux, 75002 Paris, France, e-mail: regulatory@neurim.com

Product name and form

Slenyto 1 mg prolonged-release tablets.

Slenyto 5 mg prolonged-release tablets.

Pharmaceutical Form

Prolonged-release tablet.

Slenyto 1 mg prolonged-release tablets: Pink, film coated, round, biconvex, 3 mm diameter tablets with no imprint.

Slenyto 5 mg prolonged-release tablets: Yellow, film coated, round, biconvex, 3 mm diameter tablets with no imprint.

Qualitative and quantitative composition

Slenyto 1 mg prolonged-release tablets

Each prolonged-release tablet contains 1 mg melatonin.

Excipient with known effect: Each prolonged-release tablet contains lactose monohydrate equivalent to 8.32 mg lactose.

Slenyto 5 mg prolonged-release tablets

Each prolonged-release tablet contains 5 mg melatonin.

Excipient with known effect: Each prolonged-release tablet contains lactose monohydrate equivalent to 8.86 mg lactose.

For the full list of excipients, see section 6.1.

Active Ingredient

Melatonin is a naturally occurring hormone produced by the pineal gland and is structurally related to serotonin. Physiologically, melatonin secretion increases soon after the onset of darkness, peaks at 2-4 am and diminishes during the second half of the night. Melatonin is associated with the control of circadian rhythms and entrainment to the light-dark cycle. It is also associated with a hypnotic effect and increased propensity for sleep.

List of Excipients

Slenyto 1 mg prolonged-release tablet

Tablet core:

Ammonio methacrylate copolymer type B
Calcium hydrogen phosphate dihydrate
Lactose monohydrate
Silica, colloidal anhydrous
Talc
Magnesium stearate

Film coating:

Carmellose sodium (E466)
Maltodextrin
Glucose monohydrate
Lecithin (E322)
Titanium dioxide (E171)
Iron oxide red (E172)
Iron oxide yellow (E172)

Slenyto 5 mg prolonged-release tablet

Tablet core:

Ammonio methacrylate copolymer type A
Calcium hydrogen phosphate dihydrate
Lactose monohydrate
Silica, colloidal anhydrous
Magnesium stearate

Film coating:

Carmellose sodium (E466)
Maltodextrin
Glucose monohydrate
Lecithin (E322)
Titanium dioxide (E171)
Iron oxide yellow (E172)

Pack sizes and marketing

Slenyto 1 mg prolonged-release tablets: PVC/PVDC opaque blister with aluminium foil backing. Pack size: 30 tablets or 60 tablets.

Slenyto 5 mg prolonged-release tablets: PVC/PVDC opaque blister with aluminium foil backing. Pack size: 30 tablets.

Not all pack sizes may be marketed.

Marketing authorization holder

RAD Neurim Pharmaceuticals EEC SARL, 4 rue de Marivaux, 75002 Paris, France, e-mail: regulatory@neurim.com

Marketing authorization dates and numbers

EU/1/18/1318/001
EU/1/18/1318/003
EU/1/18/1318/005

Date of first authorisation: 20 September 2018
Date of latest renewal: 5 June 2023

Drugs

Drug Countries
SLENYTO Austria, Estonia, Spain, Finland, France, Croatia, Ireland, Israel, Italy, Lithuania, New Zealand, Poland, United Kingdom

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