ZELARY Film-coated tablet Ref.[115280] Active ingredients: Cetirizine

Source: Health Products Regulatory Authority (ZA)  Revision Year: 2024  Publisher: Austell Pharmaceuticals (Pty) Ltd, 1 Sherborne Road, Parktown, Johannesburg, 2193, Tel: +27 11 611 1400 or +27 860 287 835

Therapeutic indications

ZELARY 10 is indicated for the symptomatic relief of allergic conditions such as allergic rhinitis, and allergic skin conditions such as urticaria.

Posology and method of administration

Posology

Adults or children 12 years of age or older

One 10 mg tablet daily.

Children 6 to 12 years old

One 10 mg tablet once daily or 5 mg (half a tablet) twice daily.

Special populations

Elderly population

No dose adjustment is necessary in healthy elderly patients with normal renal function.

Dosage in Renal impairment

In patients with renal impairment, where the creatinine clearance is less than 40 mL/min, the recommended daily dose of cetirizine should be halved.

Hepatic impairment

In moderate to severe hepatic impairment half the recommended daily dose should be used.

Paediatric population

ZELARY 10 is contraindicated in children under the age of two years, as safety and efficacy have not been demonstrated (see section 4.3).

Method of administration

ZELARY 10 is for oral administration.

Overdose

Symptoms

Drowsiness is an expected symptom of overdosage.

Adverse events reported after an intake of at least 5 times the recommended daily dose is: somnolence, confusion, diarrhoea, dizziness, fatigue, headache, malaise, mydriasis, pruritus, rash, restlessness or agitation, sedation, somnolence, stupor, tachycardia, tremor, and urinary retention.

Treatment

To date there is no specific antidote.

Cetirizine is not effectively removed by dialysis.

Further treatment is symptomatic and supportive.

Shelf life

36 months.

Special precautions for storage

Store at or below 25°C. Protect from light.

Keep blisters in carton until required for use.

Nature and contents of container

ZELARY 10 tablets are packed in PVC/PVDC Aluminium Blister.

The tablets are packed in blisters of 10’s.

The pack sizes are 1 × 10 and 3 × 10’s in a unit carton.

Not all pack sizes may be marketed.

Special precautions for disposal and other handling

No special requirements.

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