Active ingredients: Abacavir
Ziagen 20 mg/ml oral solution.
The oral solution is clear to slightly opalescent yellowish, aqueous solution which may turn into a brown colour over time.
Each ml of oral solution contains 20 mg of abacavir (as sulfate).
Excipients with known effect:
Sorbitol (E420) 340 mg/ml
Methyl parahydroxybenzoate (E218) 1.5 mg/ml
Propyl parahydroxybenzoate (E216) 0.18 mg/ml
For the full list of excipients see section 6.1.
Abacavir is a potent selective inhibitor of HIV-1 and HIV-2. The mechanism of action as to HIV, is the inhibition of the enzyme reverse transcriptase of HIV, an event that causes chain termination and stopping the replication cycle of the virus.
Sorbitol 70% (E420)
Citric acid anhydrous
Methyl parahydroxybenzoate (E218)
Propyl parahydroxybenzoate (E216)
Propylene glycol (E1520)
Artificial strawberry and banana flavours
Sodium hydroxide and/or hydrochloric acid for pH adjustment
Ziagen oral solution is supplied in high density polyethylene bottles with child-resistant closures, containing 240 ml of oral solution.
The pack also includes a polyethylene syringe-adapter and a 10 ml oral dosing syringe comprised of a polypropylene barrel (with ml graduations) and a polyethylene plunger.
ViiV Healthcare UK Limited, 980 Great West Road, Brentford, Middlesex, TW8 9GS, United Kingdom
Date of first authorisation: 8 July 1999
Date of latest renewal: 21 March 2014