Abacavir

Chemical formula: C₁₄H₁₈N₆O  Molecular mass: 286.332 g/mol  PubChem compound: 441300

Active ingredient description

Abacavir is a NRTI. It is a potent selective inhibitor of HIV-1 and HIV-2. Abacavir is metabolised intracellularly to the active moiety, carbovir 5'-triphosphate (TP). In vitro studies have demonstrated that its mechanism of action in relation to HIV is inhibition of the HIV reverse transcriptase enzyme, an event which results in chain termination and interruption of the viral replication cycle.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
J05AF06 Abacavir J Antiinfectives for systemic use → J05 Antivirals for systemic use → J05A Direct acting antivirals → J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
Discover more medicines within J05AF06

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ZIAGEN Film-coated tablet European Medicines Agency (EU) MPI, EU: SmPC
ZIAGEN Oral solution European Medicines Agency (EU) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

3D molecular structure

3D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 136470-78-5
DrugBank Drug: DB01048
KEGG Drug: D07057
PubChem Compound: 441300
RxNorm Ingredient: 190521
SNOMED-CT Concept: 387005008
Abacavir (substance)
UNII Identifier: WR2TIP26VS
ABACAVIR

Medicines

Abacavir is an active ingredient of these brands:

United States (US)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) EPZICOM as ABACAVIR SULFATE
  • (combination) TRIUMEQ as ABACAVIR SULFATE
  • (combination) TRIZIVIR as ABACAVIR SULFATE

Australia (AU)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) KIVEXA as ABACAVIR SULFATE
  • (combination) TRIUMEQ as ABACAVIR SULFATE
  • (combination) TRIZIVIR as ABACAVIR SULFATE

Austria (AT)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) KIVEXA as ABACAVIR SULFATE
  • (combination) TRIUMEQ as ABACAVIR SULFATE
  • (combination) TRIZIVIR as ABACAVIR SULFATE

Brazil (BR)

Canada (CA)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) KIVEXA as ABACAVIR SULFATE
  • (combination) TRIUMEQ as ABACAVIR SULFATE

Croatia (HR)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) TRIUMEQ as ABACAVIR SULFATE
  • (combination) TRIZIVIR as ABACAVIR SULFATE

Cyprus (CY)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) KIVALA
  • (combination) KIVEXA as ABACAVIR SULFATE
  • (combination) TRIUMEQ as ABACAVIR SULFATE

Ecuador (EC)

Estonia (EE)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) KIVEXA as ABACAVIR SULFATE
  • (combination) TRIUMEQ as ABACAVIR SULFATE
  • (combination) TRIZIVIR as ABACAVIR SULFATE

Finland (FI)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) KIVEXA as ABACAVIR SULFATE
  • (combination) TRIUMEQ as ABACAVIR SULFATE
  • (combination) TRIZIVIR as ABACAVIR SULFATE

France (FR)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) KIVEXA as ABACAVIR SULFATE
  • (combination) TRIUMEQ as ABACAVIR SULFATE
  • (combination) TRIZIVIR as ABACAVIR SULFATE

Germany (DE)

  • (combination) KIVEXA as ABACAVIR SULFATE

Hong Kong (HK)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) ABAVILAM as ABACAVIR SULFATE
  • (combination) KIVEXA as ABACAVIR SULFATE
  • (combination) TRIUMEQ as ABACAVIR SULFATE
  • (combination) TRIZIVIR as ABACAVIR SULFATE

Ireland (IE)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) KIVEXA as ABACAVIR SULFATE
  • (combination) TRIUMEQ as ABACAVIR SULFATE
  • (combination) TRIZIVIR as ABACAVIR SULFATE

Israel (IL)

Italy (IT)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) TRIUMEQ as ABACAVIR SULFATE
  • (combination) TRIZIVIR as ABACAVIR SULFATE

Japan (JP)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) EPZICOM as ABACAVIR SULFATE
  • (combination) LABAMICOM as ABACAVIR SULFATE
  • (combination) TRIUMEQ as ABACAVIR SULFATE

Lithuania (LT)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) KIVEXA as ABACAVIR SULFATE
  • (combination) TRIUMEQ as ABACAVIR SULFATE
  • (combination) TRIZIVIR as ABACAVIR SULFATE

Malta (MT)

Mexico (MX)

Netherlands (NL)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) KIVEXA as ABACAVIR SULFATE
  • (combination) TRIUMEQ as ABACAVIR SULFATE
  • (combination) TRIZIVIR as ABACAVIR SULFATE

New Zealand (NZ)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) KIVEXA as ABACAVIR SULFATE
  • (combination) TRIUMEQ as ABACAVIR SULFATE

Nigeria (NG)

  • AVOBAC as ABACAVIR SULFATE

  • (combination) TRIUMEQ as ABACAVIR SULFATE

Poland (PL)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) KIVEXA as ABACAVIR SULFATE
  • (combination) RETRIKIL
  • (combination) TRIUMEQ as ABACAVIR SULFATE
  • (combination) TRIZIVIR as ABACAVIR SULFATE

Romania (RO)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) KIVEXA as ABACAVIR SULFATE
  • (combination) TRIUMEQ as ABACAVIR SULFATE
  • (combination) TRIZIVIR as ABACAVIR SULFATE

Singapore (SG)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) KIVEXA as ABACAVIR SULFATE
  • (combination) TRIUMEQ as ABACAVIR SULFATE

South Africa (ZA)

Spain (ES)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) KIVEXA as ABACAVIR SULFATE
  • (combination) TRIUMEQ as ABACAVIR SULFATE
  • (combination) TRIZIVIR as ABACAVIR SULFATE

Tunisia (TN)

Turkey (TR)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) TRIUMEQ as ABACAVIR SULFATE

United Kingdom (UK)

  • ZIAGEN as ABACAVIR SULFATE

  • (combination) KIVEXA as ABACAVIR SULFATE
  • (combination) TRIUMEQ as ABACAVIR SULFATE
  • (combination) TRIZIVIR as ABACAVIR SULFATE

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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