Abacavir

Chemical formula: C₁₄H₁₈N₆O  Molecular mass: 286.332 g/mol  PubChem compound: 441300

Active ingredient description

Abacavir is a NRTI. It is a potent selective inhibitor of HIV-1 and HIV-2. Abacavir is metabolised intracellularly to the active moiety, carbovir 5'-triphosphate (TP). In vitro studies have demonstrated that its mechanism of action in relation to HIV is inhibition of the HIV reverse transcriptase enzyme, an event which results in chain termination and interruption of the viral replication cycle.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
J05AF06 Abacavir J Antiinfectives for systemic use → J05 Antivirals for systemic use → J05A Direct acting antivirals → J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
Discover more medicines within J05AF06

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ZIAGEN Film-coated tablet European Medicines Agency (EU) MPI, EU: SmPC
ZIAGEN Oral solution European Medicines Agency (EU) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

3D molecular structure

3D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 136470-78-5
DrugBank Drug: DB01048
KEGG Drug: D07057
PubChem Compound: 441300
RxNorm Ingredient: 190521
SNOMED-CT Concept: 387005008
Abacavir (substance)
UNII Identifier: WR2TIP26VS
ABACAVIR

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