Acetylsalicylic acid

Chemical formula: C₉H₈O₄ Molecular mass: 180.157 g/mol PubChem compound: 2244

Therapeutic indications

Acetylsalicylic acid is indicated for:

Prophylaxis after coronary interventions or surgery

Population group: only adults (18 years old or older)

Prevention of graft occlusion after Coronary Artery Bypass Grafting (CABG). Coronary angioplasty, except during the acute phase (PCI). Prevention of arteriovenous anastomosis for renal dialysis.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

75-160 mg once daily

Acute myocardial infarction

Population group: only adults (18 years old or older)

The recommended loading dose is 150-450 mg. The loading dose is administered as soon as possible after onset of symptoms.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

150-450 mg once daily

Transient ischaemic attacks

Population group: only adults (18 years old or older)

Secondary prevention of transient ischaemic attacks (TIA) and ischaemic cerebrovascular accidents (CVA), provided intracerebral haemorrhages have been ruled out.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

75-325 mg once daily

Fever, pain

Population group: only adults (18 years old or older)

Acetylsalicylic acid has analgesic, antipyretic and anti-inflammatory actions. It is indicated for the relief of headache, toothache, migraine, neuralgia, sore throat, dysmenorrhoea and the symptomatic relief of influenza, feverishness, rheumatic pains, sciatica, lumbago, fibrositis, muscular aches and pain.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

300-900 mg every 4 to 6 hours

Pain

Population group: only adolescents (12 years - 18 years old)

Acetylsalicylic acid has analgesic and anti-inflammatory actions. It is indicated for the relief of headache, toothache, migraine, neuralgia, sore throat, dysmenorrhoea and the symptomatic relief of influenza, rheumatic pains, sciatica, lumbago, fibrositis, muscular aches and pain.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

10-15 mg/kg every 4 hours

Rheumatic fever, rheumatoid arthritis, osteoarthritis (adults)

Population group: only adults (18 years old or older)

at least one of

Rheumatic fever
Rheumatoid arthritis
Osteoarthritis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

5-8 mg per day

Rheumatic fever

Population group: only adolescents (12 years - 18 years old)

Rheumatic fever

For this indication, competent medicine agencies globally authorize below treatments (click for details):

100 mg/kg body weight

Juvenile rheumatoid arthritis, osteoarthritis

Population group: only adolescents (12 years - 18 years old)

at least one of

Juvenile idiopathic arthritis
Osteoarthritis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

80 mg/kg body weight daily

Secondary prevention of myocardial infarction

Population group: only adults (18 years old or older)

Secondary prevention of myocardial infarction.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

75-160 mg once daily

Stable and unstable angina pectoris

Population group: only adults (18 years old or older)

History of unstable angina pectoris, except during the acute phase.

Prevention of cardiovascular morbidity in patients suffering from stable angina pectoris.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

75-160 mg once daily

Prophylaxis of deep vein thrombosis and pulmonary embolism

Population group: only adults (18 years old or older)

Prophylaxis of deep vein thrombosis and pulmonary embolism.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

80-200mg/day

300-325mg every second day

Migraine with or without aura

Population group: only adults (18 years old or older)

Migraine with or without aura.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

1000-3000mg

Contraindications

Acetylsalicylic acid is contraindicated in the following cases:

Contraindications for acetylsalicylic acid administration

at least one of

Bleeding
Gastrointestinal ulcer

Pregnancy

Pregnancy

Severe hepatic impairment

Hepatic failure stage IV

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Severe cardiac failure

Heart failure New York Heart Assosiation Class IV

Heparin therapy

Heparin

Methotrexate

Methotrexate

Haemophilia and thrombocytopenia

at least one of

Hemophilia
Thrombocytopenic disorder

Probenecid, benzbromarone, sulfinpyrazone

at least one of

Benzbromarone
Probenecid
Sulfinpyrazone

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