Acetylsalicylic acid

Chemical formula: C₉H₈O₄ Molecular mass: 180.157 g/mol PubChem compound: 2244

Therapeutic indications

Acetylsalicylic acid is indicated for:

Prophylaxis after coronary interventions or surgery

Population group: only adults (18 years old or older)

Prevention of graft occlusion after Coronary Artery Bypass Grafting (CABG). Coronary angioplasty, except during the acute phase (PCI). Prevention of arteriovenous anastomosis for renal dialysis.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

75-160 mg once daily

Acute myocardial infarction

Population group: only adults (18 years old or older)

Acute myocardial infarction

For this indication, competent medicine agencies globally authorize below treatments (click for details):

150-450 mg as soon as possible after onset of symptoms

Transient ischaemic attacks

Population group: only adults (18 years old or older)

Secondary prevention of transient ischaemic attacks (TIA) and ischaemic cerebrovascular accidents (CVA), provided intracerebral haemorrhages have been ruled out.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

75-325 mg once daily

Fever

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

For the symptomatic relief of feverishness.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

500-1,000 mg once, repeatable after at least 4 hours

Pain

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

The relief of mild to moderate pain including headache, migraine, toothache, period pains, sore throat, neuralgia, aches and pains.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

500-1,000 mg once, repeatable after at least 4 hours

10 mg/kg/4h or 15 mg/kg/6h

Secondary prevention of myocardial infarction

Population group: only adults (18 years old or older)

Myocardial infarction

For this indication, competent medicine agencies globally authorize below treatments (click for details):

75-160 mg once daily

Stable and unstable angina pectoris

Population group: only adults (18 years old or older)

History of unstable angina pectoris, except during the acute phase.

Prevention of cardiovascular morbidity in patients suffering from stable angina pectoris.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

75-160 mg once daily

Prophylaxis of deep vein thrombosis and pulmonary embolism

Population group: only adults (18 years old or older)

at least one of

Deep venous thrombosis
Pulmonary embolism

For this indication, competent medicine agencies globally authorize below treatments (click for details):

80-200 mg/day or 300-325 mg every second day

Migraine with or without aura

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

at least one of

Migraine with aura
Migraine without aura

For this indication, competent medicine agencies globally authorize below treatments (click for details):

1,000 - 3,000 mg daily for up to 3 days

Secondary prevention of stroke

Population group: only adults (18 years old or older)

CVA - Cerebrovascular accident

For this indication, competent medicine agencies globally authorize below treatments (click for details):

100-300 mg/daily

Risk reduction of first myocardial infarction in patients with high cardiovascular risk

Population group: only adults (18 years old or older)

To reduce the risk of first myocardial infarction in patients with very high cardiovascular risk (such as people with diabetes mellitus, hyperlipidemia, hypertension, obesity, smoking, old age).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

100 mg/day or 300 mg every other day

Contraindications

Acetylsalicylic acid is contraindicated in the following cases:

Peptic ulcer, gastric or intestinal haemorrhage

at least one of

Peptic ulcer
H/O: peptic ulcer
Gastric hemorrhage
Intestinal hemorrhage

Pregnancy - third trimester

Pregnancy

Severe hepatic impairment

Hepatic failure stage IV

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Severe cardiac failure

Heart failure New York Heart Assosiation Class IV

Heparin therapy

Heparin

Methotrexate used at doses >15 mg/week

Methotrexate

Haemorrhagic diathesis, coagulation disorders

Blood coagulation disorder

Acquired and congenital bleeding conditions

Bleeding

History of asthma caused by salicylates or NSAIDs

at least one of

H/O: asthma
Non-steroidal anti-inflammatory drug exacerbated respiratory disease

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