Adapalene is a retinoid-like compound which in, in vivo and in vitro models of inflammation, has been demonstrated to possess anti-inflammatory properties. Mechanically, adapalene binds like tretinoin to specific retinoic acid nuclear receptors but, unlike tretinoin not to cytosolic receptor binding proteins. Adapalene is used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
Adapalene is the active ingredient of these drugs:
Poland
Tunisia
Hong Kong
Brazil
Cyprus
Brazil
Brazil
Brazil
South Africa
Brazil Ecuador South Africa
Ecuador
Singapore
Austria Brazil Canada Ecuador Estonia
France Lithuania Spain Tunisia
Hong Kong
Hong Kong
Hong Kong
Hong Kong
Hong Kong
South Africa
Hong Kong
Ecuador
Adapalene is also found within below combination drugs:
ADACNE CLIN , CLINDENO , DERIVA C , DERMAVITAL , DERMOTOPIC DUO , EFFEZEL , EPIDUO , TACTUPUMP , ZUDENINA PB , ZUDENINA PLUS