Adapalene
Chemical formula: C₂₈H₂₈O₃ Molecular mass: 412.52 g/mol PubChem compound: 60164
Active ingredient description
Adapalene is a retinoid-like compound which in, in vivo and in vitro models of inflammation, has been demonstrated to possess anti-inflammatory properties. Mechanically, adapalene binds like tretinoin to specific retinoic acid nuclear receptors but, unlike tretinoin not to cytosolic receptor binding proteins. Adapalene is used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions.
Medicine classification
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC Group | Classification | |
|---|---|---|
| D10AD03 | Adapalene | D Dermatologicals → D10 Anti-acne preparations → D10A Anti-acne preparations for topical use → D10AD Retinoids for topical use in acne |
Product monographs
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Document | Type | Information Source | |
|---|---|---|---|
| DIFFERIN Cream | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) |
Structural formula
3D molecular structure
External identifiers
Medicines
Adapalene is an active ingredient of these brands:
Australia (AU)
Austria (AT)Brazil (BR)
Canada (CA)Croatia (HR)Cyprus (CY)Ecuador (EC)
Estonia (EE)Finland (FI)France (FR)Hong Kong (HK)Ireland (IE)Israel (IL)Japan (JP)Lithuania (LT)Malta (MT)Netherlands (NL)New Zealand (NZ)Nigeria (NG)Poland (PL)Romania (RO)
Singapore (SG)South Africa (ZA)Spain (ES)Tunisia (TN)Turkey (TR)
United Kingdom (UK)United States (US)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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