Adapalene

Active ingredient description

Adapalene is a retinoid-like compound which in, in vivo and in vitro models of inflammation, has been demonstrated to possess anti-inflammatory properties. Mechanically, adapalene binds like tretinoin to specific retinoic acid nuclear receptors but, unlike tretinoin not to cytosolic receptor binding proteins. Adapalene is used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
Adapalene
D Dermatologicals → D10 Anti-acne preparations → D10A Anti-acne preparations for topical use → D10AD Retinoids for topical use in acne
Discover more medicines within D10AD03

Medicines

Adapalene is the active ingredient of these drugs:

Drug
Countries

Poland

Tunisia

Hong Kong

Brazil

Cyprus

Brazil

Brazil

Brazil

Brazil

Singapore

Austria Brazil Canada Finland Hong Kong

France Lithuania Spain Tunisia

Hong Kong

Hong Kong

Hong Kong

Hong Kong

Hong Kong

Hong Kong

Adapalene is also found within below combination drugs:

ADACNE CLIN , DERIVA C MICRO , EFFEZEL , EPIDUO , TACTUPUMP

Product monographs

Medicine agencies around the world have authorized marketing of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Summary of product characteristics (SPC)
UK

Structural formula

Graphic representation of the active ingredient's molecular structure

3D molecular structure

3D representation of the active ingredient's molecular structure

Unique ingredient identifier (UNII)

1L4806J2QF - ADAPALENE

CAS registry number

106685-40-9 - adapalene

SNOMED-CT

332377001 - Adapalene (substance)

386934008 - Adapalene (substance)