Adapalene

Chemical formula: C₂₈H₂₈O₃  Molecular mass: 412.52 g/mol  PubChem compound: 60164

Active ingredient description

Adapalene is a retinoid-like compound which in, in vivo and in vitro models of inflammation, has been demonstrated to possess anti-inflammatory properties. Mechanically, adapalene binds like tretinoin to specific retinoic acid nuclear receptors but, unlike tretinoin not to cytosolic receptor binding proteins. Adapalene is used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
D10AD03 Adapalene D Dermatologicals → D10 Anti-acne preparations → D10A Anti-acne preparations for topical use → D10AD Retinoids for topical use in acne
Discover more medicines within D10AD03

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
DIFFERIN Cream Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

3D molecular structure

3D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 106685-40-9
DrugBank Drug: DB00210
KEGG Drug: D01112
PubChem Compound: 60164
RxNorm Ingredient: 60223
SNOMED-CT Concept: 332377001
Adapalene (substance)
SNOMED-CT Concept: 386934008
Adapalene (substance)
UNII Identifier: 1L4806J2QF
ADAPALENE

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