Therapeutic indications

Adapalene is indicated for:

Acne vulgaris

Irrespective of gender only Adolescents (12 years - 18 years old) , Adults (18 - 65 years old)

Adapalene is proposed for the cutaneous treatment of mild to moderate acne vulgaris where comedones, papules and pustules predominate. Acne of the face, chest or back is appropriate for treatment. 2

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Cutaneous - once a day before retiring


Active ingredient Adapalene is contraindicated in the following cases:


No study on animal or human milk transfer was conducted after cutaneous application of adapalene. No effects on the suckling child are anticipated since the systemic exposure of the breast-feeding woman to adapalene is negligible. Adapalene can be used during breastfeeding. To avoid contact exposure of the infant, application of adapalene to the chest should be avoided when used during breast-feeding. 2


Adapalene is contraindicated in pregnancy, or in women planning a pregnancy. Animal studies by the oral route have shown reproductive toxicity at high systemic exposure. Clinical experience with locally applied adapalene in pregnancy is limited but the few available data do not indicate harmful effects on pregnancy or on the health of the foetus exposed in early pregnancy. Due to the limited available data and because a very weak cutaneous passage of adapalene is possible, adapalene should not be used during pregnancy. If the product is used during pregnancy, or if the patient becomes pregnant while taking this drug, treatment should be discontinued.

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