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Adefovir dipivoxil

Description

Adefovir dipivoxil is an oral prodrug of adefovir, an acyclic nucleotide phosphonate analogue of adenosine monophosphate, which is actively transported into mammalian cells where it is converted by host enzymes to adefovir diphosphate. Adefovir diphosphate inhibits viral polymerases by competing for direct binding with the natural substrate (deoxyadenosine triphosphate) and, after incorporation into viral DNA, causes DNA chain termination.

ATC Classification

Code
Title
Category
J05AF08
Adefovir dipivoxil
J Antiinfectives for systemic use → J05 Antivirals for systemic use → J05A Direct acting antivirals → J05AF Nucleoside and nucleotide reverse transcriptase inhibitors

Trade names

Trade name
Countries

Austria Canada Cyprus France Netherlands

Product Monographs

Monograph
Type
Country
HEPSERA Tablet
MPI, EU: SmPC