Adefovir dipivoxil

Active ingredient description

Adefovir dipivoxil is an oral prodrug of adefovir, an acyclic nucleotide phosphonate analogue of adenosine monophosphate, which is actively transported into mammalian cells where it is converted by host enzymes to adefovir diphosphate. Adefovir diphosphate inhibits viral polymerases by competing for direct binding with the natural substrate (deoxyadenosine triphosphate) and, after incorporation into viral DNA, causes DNA chain termination.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Adefovir dipivoxil
J Antiinfectives for systemic use → J05 Antivirals for systemic use → J05A Direct acting antivirals → J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
Discover more medicines within J05AF08


Adefovir dipivoxil is the active ingredient of these drugs:


Austria Brazil Canada Cyprus Estonia

Hong Kong

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Summary of Product Characteristics (SPC)

Structural formula

Graphic representation of the active ingredient's molecular structure

Molecular mass: 501.471 g/mol

External identifiers

CAS Substance: 106941-25-7
CAS Substance: 142340-99-6
DrugBank Drug: DB00718
KEGG Drug: D01655
RxNorm Ingredient: 141400
SNOMED-CT Concept: 409114008
Adefovir dipivoxil (substance)
UNII Identifier: 6GQP90I798
UNII Identifier: U6Q8Z01514