Adefovir dipivoxil

Active ingredient description

Adefovir dipivoxil is an oral prodrug of adefovir, an acyclic nucleotide phosphonate analogue of adenosine monophosphate, which is actively transported into mammalian cells where it is converted by host enzymes to adefovir diphosphate. Adefovir diphosphate inhibits viral polymerases by competing for direct binding with the natural substrate (deoxyadenosine triphosphate) and, after incorporation into viral DNA, causes DNA chain termination.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
Adefovir dipivoxil
J Antiinfectives for systemic use → J05 Antivirals for systemic use → J05A Direct acting antivirals → J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
Discover more medicines within J05AF08

Medicines

Adefovir dipivoxil is the active ingredient of these drugs:

Drug
Countries

Austria Brazil Canada Cyprus Finland

Hong Kong

Product monographs

Medicine agencies around the world have authorized marketing of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Summary of product characteristics (SPC)

Structural formula

Graphic representation of the active ingredient's molecular structure

Unique ingredient identifier (UNII)

6GQP90I798 - ADEFOVIR

U6Q8Z01514 - ADEFOVIR DIPIVOXIL

CAS registry number

106941-25-7 - adefovir

SNOMED-CT

409114008 - Adefovir dipivoxil (substance)