Adefovir dipivoxil

Description

Adefovir dipivoxil is an oral prodrug of adefovir, an acyclic nucleotide phosphonate analogue of adenosine monophosphate, which is actively transported into mammalian cells where it is converted by host enzymes to adefovir diphosphate. Adefovir diphosphate inhibits viral polymerases by competing for direct binding with the natural substrate (deoxyadenosine triphosphate) and, after incorporation into viral DNA, causes DNA chain termination.

Medicine classification

ATC Code
Title
Class
Adefovir dipivoxil
J Antiinfectives for systemic use → J05 Antivirals for systemic use → J05A Direct acting antivirals → J05AF Nucleoside and nucleotide reverse transcriptase inhibitors

Medicines

Drug
Countries

Austria Canada Cyprus France Hong Kong

Hong Kong

Product monographs

Monograph
Type
Country
MPI, EU: SmPC

2D Molecule Structure

2D representation of molecule

Unique Ingredient Identifier (UNII)

6GQP90I798 - ADEFOVIR

U6Q8Z01514 - ADEFOVIR DIPIVOXIL

CAS Registry Number

106941-25-7 - adefovir

SNOMED-CT

409114008 - Adefovir dipivoxil (substance)